In Part I of this work, observers scaled colour preference, naturalness and vividness visually on interval scales (0-100) labelled by semantic categories (e.g. 'moderate', 'good' and 'very good') in the context of office lighting. Five customary light sources without object saturation effect illuminated a table with coloured objects in a real room. The observers' assessments were predicted by recent colour quality indices and selected pairs of indices combined linearly. Criterion values of the indices for 'good' colour preference and vividness were determined to provide a usable acceptance limit for the spectral design and evaluation of light sources. To predict colour preference, correlated colour temperature turned out to be useful. In Part 2 of this work, another experiment with the same method but using multi-LED spectra with more object saturation will be analysed and the two datasets will be merged.
In Part 2 of this work, observers scaled colour preference, naturalness and vividness visually on interval scales (0–100) labelled by semantic categories (e.g. ‘moderate’, ‘good’ and ‘very good’) in the context of food lighting using the same questionnaire as in Part 1. Seven multi-LED light sources with more or less object saturation effect illuminated a viewing booth with coloured food objects. The two datasets (Part 1: room + Part 2: viewing booth) were merged and the observers’ assessments were predicted by recent colour quality indices and CIELAB chroma differences. Linear combinations of selected pairs or triads of descriptors were used to predict the merged dataset. Criterion values to achieve ‘good’ preference, naturalness and vividness level were determined.
The preference for the chromaticity of high illuminance, high colour rendering LED illumination of different scenes was investigated for Chinese and European observers. An experiment about the preference for perceived illumination chromaticity was conducted with the same multi-LED light engine, same viewing booth and same coloured objects transported between Germany and China. Observer preference for perceived illumination chromaticity was significantly influenced by correlated colour temperature (2700 K–6500 K), object scene colour (red, blue or mixed), cultural background (Chinese or European origin, living in Germany or in China) and gender (men, women). The results can be used to choose an appropriate correlated colour temperature (e.g. warm white or cool white) for a high-quality lighting product to illuminate different object scenes (e.g. red or blue objects) so as to achieve good user acceptance in the global market.
Fibroblast growth factor 23 (FGF23) is a main regulator of mineral homeostasis. Low and high circulating FGF23 levels are associated with bone, renal, cardiovascular diseases, and increased mortality. Understanding the factors and signaling pathways affecting FGF23 levels is crucial for the management of these diseases and their complications. Here, we show that activation of the Jak1/Stat3 signaling pathway leads to inflammation in liver and to an increase in hepatic FGF23 synthesis, a key hormone in mineral metabolism. This increased synthesis leads to massive C‐terminal FGF23 circulating levels, the inactive C‐terminal fragment, and increased intact FGF23 levels, the active form, resulting in imbalanced production and cleavage. Liver inflammation does not lead to activation of the calcineurin‐NFAT pathway, and no signs of systemic inflammation could be observed. Despite the increase of active intact FGF23, excessive C‐terminal FGF23 levels block the phosphaturic activity of FGF23. Therefore, kidney function and renal αKlotho expression are normal and no activation of the MAPK pathway was detected. In addition, activation of the Jak1/Stat3 signaling pathway leads to high calcitriol levels and low parathyroid hormone production. Thus, JAK1 is a central regulator of mineral homeostasis. Moreover, this study also shows that in order to assess the impact of high FGF23 levels on disease and kidney function, the source and the balance in FGF23 production and cleavage are critical.
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