The efficacy of intramuscularly and intramammarily administered cefquinome was evaluated in experimental Escherichia coli mastitis in dairy cows. Forty-seven multiparous, Israeli Holstein cows in early lactation that produced at least 25 L/d of milk were used, and 400 to 750 cfu of E. coli were infused into two healthy quarters of each cow. Cows were randomly assigned to one of the following treatment groups: 1) 75 mg of cefquinome administered intramammarily three times at 12-h intervals, 2) 75 mg of cefquinome administered intramammarily three times at 12-h intervals and 1 mg/kg of cefquinome administered intramuscularly two times at a 24-h interval, 3) 1 mg/kg of cefquinome administered intramuscularly two times at a 24-h interval, and 4) 75 mg of ampicillin and 200 mg of cloxacillin administered intramammarily three times at 12-h intervals. All cows developed typical signs of acute clinical mastitis by 12 to 16 h postinoculation. Parenteral cefquinome therapy, with or without intramammary cefquinome (groups 2 and 3), significantly improved clinical recovery and return to milk production. The bacteriological cure rates were considerably and significantly higher for cows in the groups treated with cefquinome than for cows in the group treated with ampicillin and cloxacillin. This study supported the efficacy of cefquinome in the treatment of clinical coliform mastitis in dairy cows.
Recent studies indicate that partisan electoral interventions, a situation where a foreign power tries to determine the election results in another country, can have significant effects on the election results in the targeted country as well as other important influences. Nevertheless, research on this topic has been hindered by a lack of systematic data of electoral interventions. In this article, I introduce the Partisan Electoral Intervention by the Great Powers dataset (PEIG), which provides data on all such interventions by the US and the USSR/Russia between 1946 and 2000. After describing the dataset construction process, I note some interesting patterns in the data, a few of which stand in contrast to claims made about electoral interventions in the public sphere and give an example of PEIG's utility. I then describe some applications of PEIG for research on electoral interventions in particular and for peace research in general.
What are the effects of partisan electoral interventions on the subsequent character of the regime in the targeted country? Partisan electoral interventions have been frequently used by the great powers ever since the rise of meaningful competitive elections around the world. Such interventions have been found to have significant effects on the results of the intervened elections determining in many cases the identity of the winner. Nevertheless, there has been little research on the effects of partisan electoral interventions on the target’s subsequent level of democracy. This study investigates this question, testing three hypotheses derived from relevant political science literatures. I find suggestive evidence that covert electoral interventions have a significant negative effect on the target’s democracy increasing its susceptibility to a democratic breakdown. I also find preliminary evidence that the identity of the intervener has a mediating effect on the negative effects of covert interventions.
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