Corneal application of enalkiren , [N-(3 -amino-3-methyl-1-oxobutyl)-4-methoxy-L-phenylalanyl]-N-[1S,2R,33)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-hietidinamide], a renin inhibitor compound, lowered intraocular pressure (I0P) in unanesthetized rabbits and anesthetized monkeys. IOP was significantly decreased for at least 60 minutes after administration of a 0.3% solution of enalkiren in monkeys and for at least 90 minutes after the administration of 0.1% and 0.3% solutions in rabbits.Enalkiren did not affect systemic blood pressure or heart rate in anesthetized monkeys after topical application to the cornea. The IOP lowering activity of enalkiren suggests a potential functional role for the renin angiotensin system in the modulation of IOP.
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