Further studies on hexadimethrine bromide (polybrene)—an antiheparin agent

On the Anti‐inflammatory Activity of Protamine Sulphate and of Hexadimethrine Bromide, Inhibitors of Plasma Kinin Formation

“…Systemic injection of protamine caused an anaphylactoid reaction and it was considered unsuitable for further testing. The effect of these substances on mast cells has been investigated by Kimura, Young & Ebert (1959), who showed that protamine caused greater mast cell disruption than did hexadimethrine, in vitro and in vivo.…”

Studies of Basophils

“…These processes at times were accompanied by violent shock like reactions due to either the compounds themselves or the release of material such as histamine from the cells. Commercial heparin, though not identical with the endogenous heparin of man and rabbit is even when used in excessive quanti ties free of the toxic effects of its antagonists and the histamine releasers, and capable of preventing the lethal shocks these com pounds produce in some laboratory animals (25,26,27). One must, therefore, assume that the action of heparin is of a different nature.…”