Compared with traditional metal stents, biodegradable polymer stents have better biocompatibility but poorer mechanical properties in the treatment of vascular stenosis. It is necessary to improve the mechanical properties of biodegradable polymer stents for further application. For this purpose, we prepared a poly(L-lactide) braided stent covered with six-arm poly(L-lactide-co-ε-caprolactone) (6S-PLCL) coating cross-
Biopolymer coating is widely used in stent for drug delivery while few researches relate to its effect on mechanical properties. The strategy of blending poly(d, l‐lactic acid) (PDLLA) and poly(l‐lactic‐co‐glycolic acid) (PLGA) (100/0, 80/20, 50/50, wt/wt) was adopted in this study to explore solutions. Experiments on radial force, bending stiffness and surface morphology of poly(L‐lactic acid) stents were carried out to study the comprehensive influence of coatings with different formulations on the mechanical properties of stents. Results suggested that stents coated with PDLLA/PLGA (80/20) have shown the most superior radial supporting performance and axial flexibility. Moreover, scanning electron microscopic image of surface morphology of stents showed reliable adhesion between the coatings and stents. This study can provide a feasible method for improving the mechanical properties of bioresorbable vascular stents.
Beneficial from their good biosafety and bioabsorbability, polymeric biodegradable stents (BDS) have promising application prospects in the treatment of cardiovascular diseases. However, due to the low density of the polymer...
Biodegradable materials are widely used in biomedical application. Blending polymers have become a promising strategy to regulate degradation rate and expand material properties. In this study, the poly(D, L-lactic acid) (PDLLA) and polyCL-lactide-co-ɛ-caprolactone) (PLcCL) blend films with different ratios were prepared by the ultrasonic spray technology and the in vitro hydrolytic degradation tests of these films were then carried out in phosphate buffered saline with 37°C and 50°C. The in vitro degradation of the blend films were investigated via mass loss, gel permeation chromatography (GPC), scanning electron microscopy (SEM). It was found that the blended film had good miscibility and uniformity through SEM tests. Besides, the 50/50 PLcCL/PDLLA film showed the slowest degradation rate at 37°C, while at 50°C, the 100 PLcCL film had the slowest degradation. This work can provide helpful suggestions for the evaluation of biodegradable polymer coating materials in degradable polymer coated stent.
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