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Although PMMA-based biomaterials are widely used in clinics, a major hurdle, namely, their poor antimicrobial (i.e., adhesion) properties, remains and can accelerate infections. In this study, carboxylated multiwalled carbon nanotubes (CNTs) were incorporated into poly(methyl methacrylate) (PMMA) to achieve drug-free antimicrobial adhesion properties. After characterizing the mechanical/surface properties, the anti-adhesive effects against 3 different oral microbial species (Staphylococcus aureus, Streptococcus mutans, and Candida albicans) were determined for roughened and highly polished surfaces using metabolic activity assays and staining for recognizing adherent cells. Carboxylated multiwalled CNTs were fabricated and incorporated into PMMA. Total fracture work was enhanced for composites containing 1 and 2% CNTs, while other mechanical properties were gradually compromised with the increase in the amount of CNTs incorporated. However, the surface roughness and water contact angle increased with increasing CNT incorporation. Significant anti-adhesive effects (35~95%) against 3 different oral microbial species without cytotoxicity to oral keratinocytes were observed for the 1% CNT group compared to the PMMA control group, which was confirmed by microorganism staining. The anti-adhesive mechanism was revealed as a disconnection of sequential microbe chains. The drug-free antimicrobial adhesion properties observed in the CNT-PMMA composite suggest the potential utility of CNT composites as future antimicrobial biomaterials for preventing microbial-induced complications in clinical settings (i.e., Candidiasis).

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The aim of this study was to investigate the relationship between the different mechanical properties with the filler fraction of various resin composites. Mechanical properties of eighteen different resin composites were investigated in this study; flexural strength (FS), flexural modulus (FM), fracture toughness (FT), compressive strength (CS), diametral tensile strength (DTS), Barcol hardness (BH), Vickers hardness (HV), and Knoop hardness (HK). The mean values of mechanical properties and the filler fractions (V f ) obtained from the literature and the manufacturer were analyzed using Pearson's correlation test at p<0.01. The relationships were compared with the data retrieved from previous studies. Strong correlations between V f and BH/HV/HK and V f and FM were evident in the results of the present study and these results were supported by the retrieved data from previous studies. The other relationships between mechanical properties, such as that between FS and FM and between CS and HV were not significant.

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