Development of long-term antimicrobial poly(methyl methacrylate) by incorporating mesoporous silica nanocarriers

Lee, Jung Hwan; El‐Fiqi, Ahmed; Jo, Jeong-Ki; Kim, Dong-Ae; Kim, Si-Chul; Jun, Soo-Kyung; Kim, Hae‐Won; Lee, Hae‐Hyoung

doi:10.1016/j.dental.2016.09.001

Cited by 78 publications

(70 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to photopolymerization, heat cure is used in dentistry to increase the polymerization conversion and enhance the mechanical properties. Heat-cured resins are commonly used in orthodontics for making complicated functional appliances to correct severe skeletal class II and III malocclusions of preadolescent patients and for fabricating retainers to keep the esthetic results of orthodontic treatment [1,67,68]. The complex designing of appliances and retainers may prevent effective cleaning, thus inducing caries, periodontal diseases, and even denture-induced stomatitis in acrylate resin wearers [1,69,70].…”

Section: Protein-repellent and Antibacterial Pmma Resin To Suppress Bmentioning

confidence: 99%

“…Moreover, Takahashi et al [21] suggested that polymethyl methacrylate-(PMMA-) based acrylic resins had a relatively high 7 International Journal of Polymer Science water absorption capacity and were prone to dental plaque accumulation. Because the appliances and retainers would wear at least 2 years in the patient's mouth, so the accumulation of biofilms and plaque on the resin surfaces could create unfavorable odors and further accelerate oral bacteria-related infection [67]. Although adequate cleaning of the appliances and retainers is imperative for the prevention of bacterial related diseases, it is more beneficial and necessary to develop an antibacterial resin surface.…”

Section: Protein-repellent and Antibacterial Pmma Resin To Suppress Bmentioning

confidence: 99%

See 1 more Smart Citation

Novel Protein-Repellent and Antibacterial Resins and Cements to Inhibit Lesions and Protect Teeth

Cao

Zhang

et al. 2019

International Journal of Polymer Science

View full text Add to dashboard Cite

Orthodontic treatment is increasingly popular as people worldwide seek esthetics and better quality of life. In orthodontic treatment, complex appliances and retainers are placed in the patients’ mouths for at least one year, which often lead to biofilm plaque accumulation. This in turn increases the caries-inducing bacteria, decreases the pH of the retained plaque on an enamel surface, and causes white spot lesions (WSLs) in enamel. This article reviews the cutting-edge research on a new class of bioactive and therapeutic dental resins, cements, and adhesives that can inhibit biofilms and protect tooth structures. The novel approaches include the use of protein-repellent and anticaries polymeric dental cements containing 2-methacryloyloxyethyl phosphorylcholine (MPC) and dimethylaminododecyl methacrylate (DMAHDM); multifunctional resins that can inhibit enamel demineralization; protein-repellent and self-etching adhesives to greatly reduce oral biofilm growth; and novel polymethyl methacrylate resins to suppress oral biofilms and acid production. These new materials could reduce biofilm attachment, raise local biofilm pH, and facilitate the remineralization to protect the teeth. This novel class of dental resin with dual benefits of antibacterial and protein-repellent capabilities has the potential for a wide range of dental and biomedical applications to inhibit bacterial infection and protect the tissues.

show abstract

Section: Protein-repellent and Antibacterial Pmma Resin To Suppress Bmentioning

confidence: 99%

Section: Protein-repellent and Antibacterial Pmma Resin To Suppress Bmentioning

confidence: 99%

Novel Protein-Repellent and Antibacterial Resins and Cements to Inhibit Lesions and Protect Teeth

Cao

Zhang

et al. 2019

International Journal of Polymer Science

View full text Add to dashboard Cite

show abstract

“…Zhang et al used chlorhexidine-loaded MSN adhesive to inhibit bacteria growth over 1 day, with release shown for 16 days [96]. Lee et al used amphotericin B-loaded MSNs in a polymethyl methacrylate matrix but observed near complete release in 50 days [117]. In these studies, the limits of drug loading within MSNs has resulted in insufficient longevity.…”

Section: Current Work To Reduce Biodegradation and Secondary Cariesmentioning

confidence: 99%

Biostable, antidegradative and antimicrobial restorative systems based on host-biomaterials and microbial interactions

Stewart

Finer

2019

Dental Materials

View full text Add to dashboard Cite

Objectives: Despite decades of development and their status as the restorative material of choice for dentists, resin composite restoratives and adhesives exhibit a number of shortcomings that limit their long-term survival in the oral cavity. Herein we review past and current work to understand these challenges and approaches to improve dental materials and extend restoration service life. Methods: Peer-reviewed work from a number of researchers as well as our own are summarized and analyzed. We also include yet-unpublished work of our own. Challenges to dental materials, methods to assess new materials, and recent material improvements and research directions are presented. Results: Mechanical stress, host- and bacterial- biodegradation, and secondary caries formation all contribute to restoration failure. In particular, several host- and bacterial-derived enzymes degrade the resin and collagen components of the hybrid layer, expanding the marginal gap and increasing access to bacteria and saliva. Furthermore, the virulence of cariogenic bacteria is up-regulated by resin biodegradation by-products, creating a positive feedback loop that increases biodegradation. These factors work synergistically to degrade the restoration margin, leading to secondary caries and restoration failure. Significant progress has been made to produce hydrolytically stable resins to resist biodegradation, as well as antimicrobial materials to reduce bacterial load around the restoration. Ideally, these two approaches should be combined in a holistic approach to restoration preservation. Significance: The oral cavity is a complex environment that poses an array of challenges to long-term material success; materials testing conditions should be comprehensive and closely mimic pathogenic oral conditions.

show abstract

“…In parallel, the incorporation of silica nanoparticles (SiNPs) has been shown to enhance the mechanical properties of hydrogels, [49][50][51][52][53] enhances biological activity of biomaterials 54 and has been widely studied in the field of drug delivery. [55][56][57][58][59][60] SiNPs are particularly interesting candidates due to their low cost, limited cytotoxicity, ease of synthesis, and the versatility of sol-gel chemistry that offers various routes to conjugate biomolecules at the NP surface, while preserving their molecular recognition properties. 61,62 Here we combine self-assembled PA matrices with SiNPs to design novel SiNP-PA composite biomaterials (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Multivalent Clustering of Adhesion Ligands in Nanofiber-Nanoparticle Composites

Dems

Freeman

Coradin

et al. 2020

Preprint

View full text Add to dashboard Cite

Because the positioning and clustering of biomolecules within the extracellular matrix dictates cell behaviors, the engineering of biomaterials incorporating bioactive epitopes with spatial organization tunable at the nanoscale is of primary importance. Here we used a highly modular composite approach combining peptide amphiphile (PA) nanofibers and silica nanoparticles, which are both easily functionalized with one or several bioactive signals. We show that the surface of silica nanoparticles allows the clustering of RGDS bioactive signals leading to ASSOCIATED CONTENT Supporting Information. Characterization of the synthesized peptides; Characterization of the synthesized PAs; SiNPs characterization; Synthesis and characterization of peptide-conjugated SiNPs; Quantification of surface functionalization -Copper-free Click Chemistry Cy3-Azide; Characterization of the self-assembly of the different PA mixtures by TEM; SEM characterization of the PA layers; 3T3 fibroblasts cultured on non-functionalized SiNP/PA composites; 3T3 fibroblasts cultured on PA-PHSRN and SiNP-PHSRN/PA scaffolds. AUTHOR INFORMATION Corresponding Author

show abstract

Development of long-term antimicrobial poly(methyl methacrylate) by incorporating mesoporous silica nanocarriers

Cited by 78 publications

References 51 publications

Novel Protein-Repellent and Antibacterial Resins and Cements to Inhibit Lesions and Protect Teeth

Novel Protein-Repellent and Antibacterial Resins and Cements to Inhibit Lesions and Protect Teeth

Biostable, antidegradative and antimicrobial restorative systems based on host-biomaterials and microbial interactions

Multivalent Clustering of Adhesion Ligands in Nanofiber-Nanoparticle Composites

Contact Info

Product

Resources

About