Biostable, antidegradative and antimicrobial restorative systems based on host-biomaterials and microbial interactions

Stewart, Cameron A.; Finer, Yoav

doi:10.1016/j.dental.2018.09.013

Cited by 65 publications

(59 citation statements)

References 114 publications

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“…Utilizing drug-carrier particles to store and release drugs without forming voids can bypass these problems and prolong release by the limited diffusion of media into the particle, and subsequent diffusion of the drug out [ 49 ]. Mesoporous silica nanoparticles (MSNs) are a promising carrier that can store large amounts of drugs in their pores and extend release by limiting drug diffusion [ 50 ].…”

Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

“…However, the effect of biodegradation on many antimicrobial monomers is unknown. For those which contain unprotected and easily hydrolyzed bonds, degradation may happen and thus release toxic degradation products, even though they are covalently attached to the matrix [ 49 ]. In sum, the long-term biocompatibility of antimicrobial modified resin composites should be studied.…”

Section: Challenges Faced By Antimicrobial Dental Restorationsmentioning

confidence: 99%

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Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Sun¹,

Zhang²,

Bai³

et al. 2021

Polymers

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Repairing tooth defects with dental resin composites is currently the most commonly used method due to their tooth-colored esthetics and photocuring properties. However, the higher than desirable failure rate and moderate service life are the biggest challenges the composites currently face. Secondary caries is one of the most common reasons leading to repair failure. Therefore, many attempts have been carried out on the development of a new generation of antimicrobial and therapeutic dental polymer composite materials to inhibit dental caries and prolong the lifespan of restorations. These new antimicrobial materials can inhibit the formation of biofilms, reduce acid production from bacteria and the occurrence of secondary caries. These results are encouraging and open the doors to future clinical studies on the therapeutic value of antimicrobial dental resin-based restoratives. However, antimicrobial resins still face challenges such as biocompatibility, drug resistance and uncontrolled release of antimicrobial agents. In the future, we should focus on the development of more efficient, durable and smart antimicrobial dental resins. This article focuses on the most recent 5 years of research, reviews the current antimicrobial strategies of composite resins, and introduces representative antimicrobial agents and their antimicrobial mechanisms.

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Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

Section: Challenges Faced By Antimicrobial Dental Restorationsmentioning

confidence: 99%

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Sun¹,

Zhang²,

Bai³

et al. 2021

Polymers

View full text Add to dashboard Cite

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“…Patient characteristics include high caries-risk, gingival cavity margins, and posterior teeth [ 15 ]. Indeed, most dental resins are degraded by the caustic conditions present in the oral cavity and this activity leads to the long-term release of degradation by-products [ 16 , 17 ]. These by-products accumulate at the resin/tooth interface and increase the virulence of cariogenic bacteria, provoking a degradative positive-feedback loop [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, most dental resins are degraded by the caustic conditions present in the oral cavity and this activity leads to the long-term release of degradation by-products [16,17]. These by-products accumulate at the resin/tooth interface and increase the virulence of cariogenic bacteria, provoking a degradative positive-feedback loop [16]. This degradative feedback loop is central to the failure of dental adhesives.…”

Section: Introductionmentioning

confidence: 99%

Evolution of Network Structure and Mechanical Properties in Autonomous-Strengthening Dental Adhesive

Sarikaya

Song

et al. 2020

Polymers

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The inherent degradation property of most dental resins in the mouth leads to the long-term release of degradation by-products at the adhesive/tooth interface. The by-products increase the virulence of cariogenic bacteria, provoking a degradative positive-feedback loop that leads to physicochemical and mechanical failure. Photoinduced free-radical polymerization and sol‒gel reactions have been coupled to produce a novel autonomous-strengthening adhesive with enhanced hydrolytic stability. This paper investigates the effect of network structure on time-dependent mechanical properties in adhesives with and without autonomous strengthening. Stress relaxation was conducted under 0.2% strain for 8 h followed by 40 h recovery in water. The stress‒time relationship is analyzed by nonlinear least-squares data-fitting. The fitted Prony series predicts the sample’s history under monotonic loading. Results showed that the control failed after the first loading‒unloading‒recovery cycle with permanent deformation. While for the experimental sample, the displacement was almost completely recovered and the Young’s modulus increased significantly after the first test cycle. The experimental polymer exhibited higher degree of conversion, lower leachate, and time-dependent stiffening characteristics. The autonomous-strengthening reaction persists in the aqueous environment leading to a network with enhanced resistance to deformation. The results illustrate a rational approach for tuning the viscoelasticity of durable dental adhesives.

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“…The interface between tooth and orthodontic bonding adhesive or cement, many of them based on (meth)acrylate chemistry, could also become the victim of bacterial attack and subsequent degradation [ 20 , 21 ]. Finer et al’s findings revealed increased degradation of resin-based composite and bonding agent by S. mutans UA159 vs. control.…”

Section: Introductionmentioning

confidence: 99%

Novel Orthodontic Cement Comprising Unique Imidazolium-Based Polymerizable Antibacterial Monomers

Jin

2020

JFB

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White spot lesions (WSLs) can develop quickly and compromise the successful outcome of the orthodontic treatment. Orthodontic bonding cement with the capability to prevent or mitigate WSLs could be beneficial, especially for patients with high risk of caries. This study explored novel mono- and di-imidazolium-based polymerizable antibacterial monomers and evaluated orthodontic cement compositions comprising such novel monomers. Their antibacterial potentials, mechanical properties, and shear bond strength (SBS) to bovine enamel were investigated. Statistical tests were applied to SBS and mechanical tests (one-way ANOVA and Tukey’s test). For antibacterial resins C (ABR-C) and E (ABR-E), their minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against cariogenic Streptococcus mutans bacterial strain UA159 were found to be 4 μg/mL and 8 μg /mL, respectively. The loss of dry mass from completely demineralized dentin beams in buffer solutions pre-dipped into ABR-C and ABR-E resins is much less than that in control buffer (artificial saliva) only. For unfilled resins comprising up to 12 wt % ABR-C, no significant decreases in flexural strength or modulus were observed. For experimental cements incorporating 1–4 wt % ABR-C, there was no drastic compromise to the SBS to enamel except for 3 wt % ABR-C. Furthermore, their SBS was all comparable to the commercially available orthodontic cements. The ISO-22196 antimicrobial test against S. aureus showed significant levels of antibacterial effects—up to over 5 logs of microorganism reduction exhibited by ABR-C-containing experimental cements. The imidazolium-based polymerizable monomers could be utilized to functionalize orthodontic bonding cement with steady antibacterial activity and develop a potential strategy to counteract WSLs.

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Biostable, antidegradative and antimicrobial restorative systems based on host-biomaterials and microbial interactions

Cited by 65 publications

References 114 publications

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Evolution of Network Structure and Mechanical Properties in Autonomous-Strengthening Dental Adhesive

Novel Orthodontic Cement Comprising Unique Imidazolium-Based Polymerizable Antibacterial Monomers

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