Objective: Serum sodium levels change in patients with lung infections. This study aimed to evaluate serum sodium levels in patients who were admitted to the hospital with a lower respiratory tract infection (LRTI) and to assess its association with C-reactive protein (CRP) levels. Material and Methods: A cross-sectional study was designed. A total of 549 inpatients (207 females, 37.7%; 342 males, 62.3%) aged 1-15 years who were diagnosed with LRTI (pneumonia, bronchitis, and bronchiolitis) at the Kars State Hospital's pediatric ward between 01.01.2011 and 30.06.2014 were included in the study. The records of these patients were retrospectively reviewed. Age, gender, white blood cell (WBC) count, absolute neutrophil count (ANC), sodium levels, and CRP levels were recorded. The patients were classified into five groups according to serum sodium levels as severe hyponatremia, moderate hyponatremia, mild hyponatremia, normonatremia, and hypernatremia. Results: There was no significant difference for age or gender between the hyponatremia and normonatremia groups. There was one patient with severe hyponatremia (≤125 mmol/L), nine with moderate hyponatremia (126-130 mmol/L), 90 with mild hyponatremia (131-134 mmol/L), 446 with normonatremia (135-145 mmol/L), and three with hypernatremia (≥146 mmol/L). There was a negative correlation between serum sodium levels and CRP levels (r=-0.178; p<0.001), WBC counts (r=-0.121; p=0.004), and ANC (r=-0.100; p=0.048). Conclusion: There was a statistically significant negative correlation between serum sodium levels and acutephase reactants in patients with pneumonia. Serum sodium levels must be closely monitored in these patients, particularly when acute-phase reactant levels are high.
Familial Mediterranean Fever (FMF) is an autosomal recessive hereditary disease that affects mainly the people of Jewish, Arabic, Turkish, and Armenian origins. FMF is a disease characterized by recurrent fever, abdominal pain, pleuritis, arthritis, and erysipelas-like skin lesion. The diagnosis of FMF is based on clinical manifestations; therefore, diagnostic difficulties are experienced in many FMF patients. This article is focused on a diagnostic approach to the FMF disease. (JAREM 2015; 5: 89-93)
Our aim was to investigate the protective role of ozone treatment against gentamicin-induced nephrotoxicity in an experimental rat model. In this study, a total of 30 rats were allocated in 5 groups (n=6 in each group). The control group (Group 1) received isotonic saline only, while Groups 2 and 3 received gentamicin at doses of 15 mg/kg/day and 50 mg/kg/day, respectively. In Group 4, intraperitoneal ozone treatment (1 mg/kg, 5% O3-95% O2) was performed after administration of gentamicin at a dose of 15 mg/kg/day. Group 5 underwent ozone treatment intraperitoneally following the application of gentamicin (50 mg/kg/day). Nephrotoxicity was formed by administration of glycerol. Serum levels of urea, creatinine, neutrophil-gelatinase-associated lipocalin (NGAL), lactate dehydrogenase (LDH), total antioxidant capacity (TAC) and protein carbonyl were measured, and kidneys were histopathologically examined after the sacrifice of animals on the 5 th day. Group 4 displayed more favorable outcomes regarding biochemical markers of oxidative stress such as NGAL, LDH, creatinine, urea, TAC and protein carbonyl. Similarly, histopathological alterations indicating gentamicin-induced nephrotoxicity such as hemorrhage, the presence of protein casts and epithelial injury in renal tubules were less evident in Groups 4 and 5 which received ozone treatment. To conclude, results of this experimental study demonstrated that ozone treatment might ameliorate biochemical disturbances and histopathological alterations linked with gentamicininduced nephrotoxicity. However, further trials are warranted to document the actual therapeutic potential of ozone treatment in the clinical setting.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.