Donatella Bagetta scite author profile

Because of the lack of significant disease-modifying drugs for neurodegenerative disorders, a pressing need for new chemical entities endowed with IMAO-B still exists. Within this framework, and for the first time, a study was performed to compare coumarin- and chomone-3-phenylcarboxamide scaffolds. Compounds 10a and 10b were the most potent, selective, and reversible noncompetitive IMAO-B. The benzopyrone sp oxygen atom was found to be position independent and a productive contributor for the ligand-enzyme complex stability.

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A computer-assisted discovery of novel potential anti-obesity compounds as selective carbonic anhydrase VA inhibitors

Costa

Carta

Ambrosio

et al. 2019

European Journal of Medicinal Chemistry

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N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study

Marques

López

Bagetta

et al. 2020

Bioorganic Chemistry

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Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents

Carradori

Ortuso

Petzer

et al. 2018

European Journal of Medicinal Chemistry

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