The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile

Maruca, Annalisa; Catalano, Raffaella; Bagetta, Donatella; Mesiti, Francesco; Ambrosio, Francesca Alessandra; Romeo, Isabella; Moraca, Federica; Rocca, Roberta; Ortuso, Francesco; Artese, Anna; Costa, Giosuè; Alcaro, Stefano; Lupia, Antonio

doi:10.1016/j.ejmech.2019.111579

Cited by 55 publications

(41 citation statements)

References 218 publications

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“…Cancer is the second largest single cause of death worldwide [35] and over the next twenty years is expected to rise by about 70%. The modern therapies have improved cancer patients' life and chemoprevention with natural compounds is an emerging strategy to avoid and cure the tumor [3]. Different studies on plants and natural compounds have led to the discovery of many drugs, such as taxol, vincristine, vinblastine, and camptothecin [36,37].…”

Section: Resultsmentioning

confidence: 99%

“…Several factors affect the composition of EOS, such as the plant variety, the growth area, climatic changes, storage conditions and extraction methods. Typically, monoterpenes are the most abundant constituents and, often, the biological activities of EOs have been related to their presence in the phytocomplex [2,3]. Traditionally, EOs have been used for their biological activities including antibacterial, antifungal, sedative, antioxidant, spasmolytic, carminative, hepatoprotective, and analgesic effects.…”

Section: Introductionmentioning

confidence: 99%

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Multi-Targeting Bioactive Compounds Extracted from Essential Oils as Kinase Inhibitors

et al. 2020

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Essential oils (EOs) are popular in aromatherapy, a branch of alternative medicine that claims their curative effects. Moreover, several studies reported EOs as potential anti-cancer agents by inducing apoptosis in different cancer cell models. In this study, we have considered EOs as a potential resource of new kinase inhibitors with a polypharmacological profile. On the other hand, computational methods offer the possibility to predict the theoretical activity profile of ligands, discovering dangerous off-targets and/or synergistic effects due to the potential multi-target action. With this aim, we performed a Structure-Based Virtual Screening (SBVS) against X-ray models of several protein kinases selected from the Protein Data Bank (PDB) by using a chemoinformatics database of EOs. By evaluating theoretical binding affinity, 13 molecules were detected among EOs as new potential kinase inhibitors with a multi-target profile. The two compounds with higher percentages in the EOs were studied more in depth by means Induced Fit Docking (IFD) protocol, in order to better predict their binding modes taking into account also structural changes in the receptor. Finally, given its good binding affinity towards five different kinases, cinnamyl cinnamate was biologically tested on different cell lines with the aim to verify the antiproliferative activity. Thus, this work represents a starting point for the optimization of the most promising EOs structure as kinase inhibitors with multi-target features.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multi-Targeting Bioactive Compounds Extracted from Essential Oils as Kinase Inhibitors

et al. 2020

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“…Notably, most national dietary guidelines support these same nutritional patterns, whereby high fruit, vegetable, nuts, dairy, and fish intake is promoted (48). These foods are rich in bioactive compounds with potential antithrombotic and anti-inflammatory properties as highlighted in Table 1 (41,60,(82)(83)(84)(85). These include phytochemicals such as phenolic compounds, carotenes, alkaloids, terpenes, peptides, and bioactive lipid molecules.…”

Section: Foods and Nutrients With Antithrombotic Propertiesmentioning

confidence: 99%

Thrombosis and COVID-19: The Potential Role of Nutrition

2020

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease (COVID-19), is a contagion that has rapidly spread around the globe. COVID-19 has caused significant loss of life and disrupted global society at a level never before encountered. While the disease was predominantly characterized by respiratory symptoms initially, it became clear that other systems including the cardiovascular and neurological systems were also involved. Several thrombotic complications were reported including venous thrombosis, vasculitis, cardiomyopathy, and stroke. Thrombosis and inflammation are implicated in various non-communicable diseases (NCDs). This is of significant concern as people with pre-existing conditions such as cardiovascular disorders, renal disorders, obesity, metabolic syndrome, and diabetes are at greater risk of severe COVID-19 infection. Consequently, the research surrounding the use of anticoagulants, antiplatelet, and antithrombotic strategies for prophylaxis and treatment of COVID-19 is of critical importance. The adoption of a healthy diet, physical exercise, and lifestyle choices can reduce the risk factors associated with NCDs and the thrombo-inflammatory complications. In this review, these thrombotic complications and potential foods, nutraceuticals, and the antithrombotic constituents within that may prevent the onset of severe thrombotic complications as a result of infection are discussed. While nutrition is not a panacea to tackle COVID-19, it is apparent that a patient's nutritional status may affect patient outcomes. Further intensive research is warranted to reduce to incidence of thrombotic complications.

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“…Researchers aim to identify “master keys” able to recognize sets of “multiple locks”. The purpose is to give synergistic effects in multifactorial diseases such as cancer, inflammation and metabolic and neurodegenerative disorders [ 81 , 82 , 83 ].…”

Section: Jakis As Important Players In Multifactorial Diseasesmentioning

confidence: 99%

Inside Perspective of the Synthetic and Computational Toolbox of JAK Inhibitors: Recent Updates

et al. 2020

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The mechanisms of inflammation and cancer are intertwined by complex networks of signaling pathways. Dysregulations in the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway underlie several pathogenic conditions related to chronic inflammatory states, autoimmune diseases and cancer. Historically, the potential application of JAK inhibition has been thoroughly explored, thus triggering an escalation of favorable results in this field. So far, five JAK inhibitors have been approved by the Food and Drug Administration (FDA) for the treatment of different diseases. Considering the complexity of JAK-depending processes and their involvement in multiple disorders, JAK inhibitors are the perfect candidates for drug repurposing and for the assessment of multitarget strategies. Herein we reviewed the recent progress concerning JAK inhibition, including the innovations provided by the release of JAKs crystal structures and the improvement of synthetic strategies aimed to simplify of the industrial scale-up.

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The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile

Cited by 55 publications

References 218 publications

Multi-Targeting Bioactive Compounds Extracted from Essential Oils as Kinase Inhibitors

Multi-Targeting Bioactive Compounds Extracted from Essential Oils as Kinase Inhibitors

Thrombosis and COVID-19: The Potential Role of Nutrition

Inside Perspective of the Synthetic and Computational Toolbox of JAK Inhibitors: Recent Updates

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