To determine the association between the incidence of endometrial cancer and the use of estrogen in menopausal and post-menopausal women, we retrospectively compared 317 patients with adenocarcinoma of the endometrium with an equal number of matched controls having other gynecologic neoplasms; 152 patients used estrogen, as compared to 54 of 317 controls. Thus, the risk of endometrial cancer was 4.5 times greater among women exposed to estrogen therapy. When estrogen use was adjusted for concomitant variables such as obesity, hypertension, diabetes, parity, referral pattern, age at diagnosis, year of diagnosis and other gynecologic neoplasms, the magnitude of the increased relative risk was associated with several of these variables, and was highest in patients without obesity and hypertension. Exogenous estrogen therapy is associated with an increased risk of endometrial carcinoma, but this increased relative risk is less apparent in patients with physiologic characteristics previously associated with an increased risk.

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Smith. 2347 p-ljlydroxybenzmte Group8 in the Lipin of Aspen (Populus tremula). By D. C. C. SMITH.[Reprint Order No. 6160.1 They occur singly, involving aliphatic hydroxyl groups of the " native lignin," and account for about 10% of its weight." NATIVE LIGNINS," the soluble analogues of lignins which are the aromatic substances of high molecular weight associated with woodiness in plants (

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Ultraviolet spectra of mono-and di-anions of some linear tri-P-carbonyl compounds and of acetoacetic and 3,5-dioxohexanoic acid are reported and the course of decomposition of these compounds by alkali is described. A new approach to the preparation of poly-P-diketones by ozonolysis of dihydroaromatic compounds is described, leading to a ketal of undecane-2,4,6,8,10pentaone, the first reported derivative of a linear penta-P-ketone. A new explanation is offered for the I' acidic " fission of p-keto-esters.

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The purpose of this paper is to provide the reader with a better insight into the mechanisms of multifocal ERG (mfERG) recording. The construction of the first and second order mfERG responses were examined by recovering the response to specific pulse trains embedded in the m-sequence.A custom built pc based multifocal system driving a LED stimulator was used to record a 61 element mfERG and a global ERG. The global ERG recording was used to enable the recovery of different pulse trains embedded in the m-sequence. Summation of these individual pulse trains was performed and the results compared with the standard full cross-correlation. An isolated pulse response is defined as a flash of light that has no other flashes within two m-sequence base periods before or after the flash. This isolated pulse response was recovered from the raw data and this response input into a simple superposition model to predict the waveform shape for specific pulse trains. The superposition model was compared with the actual selective cross-correlation for a particular pulse train. The summations of the selective cross-correlation components give identical responses to the full cross-correlation. The superposition model also predicts the waveform shapes recovered by the selective cross-correlation procedure. The mfERG response is a complex composite response from a number of different pulse trains. Examination of the individual waveform shapes provides some insight into the origin of the mfERG waveform. The main contributions to the P1 component are the same as for an isolated response and as with the standard ERG this component is likely to be dominated by the mid retina. The N1 component is also likely to have similar origins to that of the isolated response but the amplitude is dominated by contributions from pulse trains where there is no change of state and therefore includes a component from the interaction between two consecutive stimuli. The N2 component is a composite response dominated by the interaction between two successive stimuli two base periods apart and the P1 component of a second stimulus delayed one frame from the first stimulus.

The lactone of 8-hydroxy-1 -naphthoic acid reacts with nucleophilic reagents to give a variety of 8-hydroxy-Inaphthoyl compounds. In these an intramolecular hydrogen bond unites the hydroxy-and carbonyl functions and strongly affects ultraviolet and visible spectra, but only in non-basicsolvents. The reactions of these compounds in strong acid, and their mass spectra, are also dependent on peri-ring closures.