Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) or ulcerative colitis are chronic intestinal disorders, which are on the increase in "Westernised" countries. IBD can be caused by both genetic and environmental factors. Interleukin-10 (IL-10) is an immunoregulatory cytokine that has been identified as being involved in several diseases including IBD. Studies have shown that polymorphisms in the promoter region reduce serum levels of IL-10 and this reduction has been associated with some forms of IBD. Mouse models have shown promising results with IL-10 supplementation, as such IL-10 supplementation has been touted as being a possible alternative treatment for CD in humans. Clinical trials have shown that recombinant human IL-10 is safe and well tolerated up to a dose of 8 μg/kg. However, to date, the results of the clinical trials have been disappointing. Although CD activity was reduced as measured by the CD activity index, IL-10 supplementation did not result in significantly reduced remission rates or clinical improvements when compared to placebo. This review discusses why IL-10 supplementation is not effective in CD patients currently and what can be addressed to potentially make IL-10 supplementation a more viable treatment option in the future. Based on the current research we conclude that IL-10 supplementation is not a one size fits all treatment and if the correct population of patients is chosen then IL-10 supplementation could be of benefit.

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Distributed temperature sensing (DTS) and distributed acoustic sensing (DAS) data recorded by a fiber-optic array installed during the decommissioning operations of the 1550 m Harvey 3 well in Western Australia reveal an abundance of valuable information about the course of the decommissioning process and the quality of the cement job. The DAS monitoring has detected vibrational disturbances during the cement's setting up, while DTS was used to assess setting up of the cement and curing times as well as uniformity of cementation from the distribution of temperature along the borehole. A weeklong trial acquisition of passive seismic data with the same array a year later shows an abundance of seismic events in a wide frequency range from below 1 mHz to above 200 Hz. The downhole DAS array provides traveltimes and amplitudes of these events, which include earthquakes, mine blasts, ocean microseisms, and local human activity. The amplitudes of waves from distant seismic events can be used to estimate and monitor physical properties of the media along the extent of the well. When used in combination with information from active vertical seismic profiling, these events can help obtain independent estimates of velocities and densities. Spectral analysis of low-frequency microseisms shows a strong correlation between passively recorded DAS and local weather observations. This shows that the ability to continuously record oceanic microseisms at low frequencies opens opportunities to employ such arrays for wave climate studies. In addition, the data contain peculiar in-hole reverberations likely caused by crossflow of groundwater behind the intermediate casing, which may indicate imperfections of the cement job. The results demonstrate that a downhole fiber-optic array installed in an abandoned well represents an opportunity to establish a permanent facility for continuous recording of passive and active geophysical data and for exploring various applications.

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