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BackgroundThe present study contrasts the accuracy of different reconstructed models with distinctive segmentation methods performed by various experts. Seven research groups reconstructed nine 3D models of one human femur based on an acquired CT image using their own computational methods. As a reference model for accuracy assessment, a 3D surface scan of the human femur was created using an optical measuring system. Prior to comparison, the femur was divided into four areas; “neck and greater trochanter”, “proximal metaphysis”, “diaphysis”, and “distal metaphysis”. The deviation analysis was carried out in GEOMAGIC studio v.2013 software.ResultsThe results revealed that the highest deviation errors occurred in “neck and greater trochanter” area and “proximal metaphysis” area with RMSE of 0.84 and 0.83 mm respectively.ConclusionIn conclusion, this study shows that the average deviation of reconstructed models prepared by experts with various methods, skills and software from the surface 3D scan is lower than 0.79 mm, which is not a significant discrepancy.

In this biomechanical study on unstable proximal humerus fractures, fixation with a PEEK plate showed lower fixation strength and increased motion at the bone-implant interface compared with a titanium locking plate.

Facet Wedge offers a novel posterior approach in achieving primary stability in lumbar spinal fixation. The results of the present study showed that the Facet Wedge has a comparable primary stability to pedicle screws and potential advantages over translaminar screws.

Periprosthetic hip fractures are an increasing problem in modern orthopedic and trauma surgery. Many options for the operative treatment are available to the surgeon ranging from modern variable angular systems to standard plates, screws, and cerclages. However, there is no gold standard and therefore, the aim of this study, was to investigate the biomechanical characteristics of double plating versus a lateral standard plate in a Vancouver B1 fracture model. Ten 4th generation composite femora were used to implant cementless total hip prosthesis and create Vancouver B1 periprosthetic fractures. Afterwards, the osteotomies were fixed using the locking compression plate in combination with the locking attachment plate (LCP, LAP, DePuy Synthes, Solothurn, Switzerland)-group I. Group II additionally achieved a 5-hole 4.5/5.0 mm LCP anteriorly. Each construct was cyclically loaded to failure in axial compression. Axial construct stiffness was 50.87 N/mm (SD 1.61) for group I compared to 738.68 N/mm (SD 94.8) for group II, this difference was statistically significant (p = 0.016). The number of cycles to failure was also significant higher for group II (2,375 vs. 13,000 cycles; p = 0.016). Double plating can significantly increase construct stiffness and stability, and thus, is an option in the treatment of complex periprosthetic fractures, in revision surgery and for patients with the inability to partial weight bear. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:234-239, 2017.

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In bone tissue engineering, the design of in vitro models able to recreate both the chemical composition, the structural architecture, and the overall mechanical environment of the native tissue is still often neglected. In this study, we apply a bioreactor system where human bone-marrow hMSCs are seeded in human femoral head-derived decellularized bone scaffolds and subjected to dynamic culture, i.e., shear stress induced by continuous cell culture medium perfusion at 1.7 mL/min flow rate and compressive stress by 10% uniaxial load at 1 Hz for 1 h per day. In silico modeling revealed that continuous medium flow generates a mean shear stress of 8.5 mPa sensed by hMSCs seeded on 3D bone scaffolds. Experimentally, both dynamic conditions improved cell repopulation within the scaffold and boosted ECM production compared with static controls. Early response of hMSCs to mechanical stimuli comprises evident cell shape changes and stronger integrin-mediated adhesion to the matrix. Stress-induced Col6 and SPP1 gene expression suggests an early hMSC commitment towards osteogenic lineage independent of Runx2 signaling. This study provides a foundation for exploring the early effects of external mechanical stimuli on hMSC behavior in a biologically meaningful in vitro environment, opening new opportunities to study bone development, remodeling, and pathologies.

Currently, evaluation of the stability of spinal instrumentations often focuses on simple pull-out or cyclic loading. However, the loading characteristics and the specimen alignment rarely simulate physiological loading conditions, or the clinical situation itself. The purpose of this study was to develop an alternative setup and parameters to compare static and dynamic characteristics of pedicle screws at the bone-implant interface in lumbar osteoporotic cadavers. A corpectomy model development was based on ASTM-1717 standard, allowing a deflection of the cranial and caudal element under loading. Twelve human osteoporotic vertebrae (L1-L4) were analyzed for morphological CT-data and T-Score. For group A (n ¼ 6) loads were simulated as in vivo measurements during walking, representing 2 months postoperatively. A subsequent pull-out was performed. Group B (n ¼ 6) was tested with pure pull-out. Screw loosening at the tip/head was optically measured and analyzed with respect to clinical patterns. Correlations between CT-data, T-Score, and in vitro parameters were determined. For group A, the subsidence for the head/tip was measured towards the upper/lower endplate, resulting in visible deflections. The progress of the subsidence was greatest within the first and last cycles until failure. The predominant patterns were pure rotation and toggling. However, the pull-out between groups was not significantly different. Pedicle-angle and cyclic-subsidence correlated with R ¼ 0.806/0.794. T-Score and pull-out correlated only in group A. With the corpectomy setup, clinically observed wipe effects and a loss of correction could be simulated. The presented parameters facilitate analysis of the complex changing load distributions and interactions between the left and right bone-implant interface. ß