This case report describes a case of heterotopic cervical ectopic pregnancy in a nulliparous woman that was successfully treated with single-dose local, intra-amniotic methotrexate injection in the gestational sac. Pregnancy was achieved spontaneously. The patient had previously undergone hysteroscopic myomectomy. By using local, single-dose treatment we avoided the continued effects of the drug on the intrauterine pregnancy and the possible adverse effect of systemically applied methotrexate. The treatment resulted in the term vaginal delivery of a healthy child and preserved the patient's fertility for future pregnancies.

It is obvious that malignant neoplasms of the skin, head and neck occur after decades of exposure, and as a cumulative effect of exposure to risk factors. A direct exposure to sun seems to play an important role, especially with regard to melanoma. Nevertheless, further research is needed.

The aim of the study was to investigate health safety and quality of the Croatian acacia honey, the selected elements in the soil, and whether multivariate methods can provide identification of the origin of honey. The study included 200 acacia honey samples and 100 soil samples from East, Northwest Croatia, and Istria. The proportion of acacia in honey was determined by conducting pollen analysis. Water, free acids, electric conductivity, reducing sugars, saccharose, diastase, and HMF were determined. No significant differences were found using Kruskal-Wallis test regarding the physicochemical parameters (p=0.9190), the mineral content of honey (p=0.8955), or the mineral composition of the soil (p=0.8789). No significant correlation was found between the analyzed elements in honey and soil. Multivariate methods indicated that East Croatia honey samples have higher concentrations of water, HMF, and higher concentrations of measured elements, except for Al. Honey samples from Northwest Croatia are characterized by low concentrations of elements and a higher concentration of saccharose. The Istria samples are richer in reducing sugars, free acids, diastase, higher conductivity, higher content of the acacia pollen grains, and lower concentrations of most metals. Honey from Northwest Croatia and Istria shares the high concentration of Al in honey.

No abstract

War in Croatia resulted in a significant release of contaminants into the environment as a result of the use of combat assets, mainly conventional, mostly aimed at civilian targets. The aim of the study was to investigate the concentration of metals and metalloids in the soils of eastern Croatia. Compared with soil samples from areas exposed to low intensity combat activity soil samples from areas exposed to heavy fighting had higher concentrations of As, Hg and Pb than allowed by national legislation for ecologic farming as well as even higher concentrations of Hg than the maximum allowed values for agriculture in general. Descriptive statistics shows that mean values of Cu, Zn, Ni, Pb, P and Ba are all higher in samples collected at the areas of high combat activity compared with the ones collected from the low combat activity areas. Sb concentration was elevated in one location, which can also be correlated with population exposure. The results of the principal component analysis suggest possible correlation between the war activity and the degree of contamination by the metals found in ammunition.