The aim of the study was to evaluate the accuracy of an automated oscillometric device, Lohmeier B-606, for clinical use in hospitals, according to recently published recommendations of the Working Group of Blood Pressure Monitoring of the European Society of Hypertension.We performed 9 sequential alternate measurements (3 comparisons between the automated device and mercury sphygmomanometry) in 33 subjects (15 in a primary phase and 18 in a secondary phase) having blood pressures less than 130/60 (11 subjects), between 130-160/80-100 (11 subjects) and higher than 160/100 (11 subjects). To consider the device accurate, the 99 comparisons must reach all the following (45 comparisons Յ5 mmHg, 70 comparisons Յ10 mmHg and 85 comparisons Յ15 mmHg) and at least two of the following (50 comparisons Յ5 mmHg, 75 comparisons Յ10 mmHg and/or 90 comparisons Յ15 mmHg). Moreover, we calculated Pearson's correlation coefficients, Brand & Altman differences and limits of agreement and intraclass correlation coefficients.From the total 99 comparisons, 55, 86, and 99 for systolic BP, and 66, 88 and 99, for diastolic BP, were Յ5, Յ10 and Յ15 mmHg, respectively, thus reaching all the aforementioned criteria. Pearson's correlation coefficients were 0.976 and 0.950 for SBP abd DBP. Mean differences (95%CI) were 0.08 mmHg (-14.1,14.3) for SBP and 0.99 mmHg (-11.0,13.0) for DBP. Finally, intraclass correlation coefficients were 0.975 for SBP and 0.944 for DBP.We conclude that the automated oscillometric device Lohmeier B-606 is accurate for BP measurement, in comparison with mercury sphygmomanometry, using both European Society of Hypertension recommendations and statistical measures of agreement. Background: Previous results from our group have shown that essential hypertensive (EH) patients with silent cerebral white matter lesions (WML) exhibit high long-term systolic BP variability assessed by continuous finger monitoring. The aim of the present study was to analyze the effect of antihypertensive treatment on blood pressure variability(B-PV)in such patients.Methods: Ten matched EH patients (four with silent cerebral white matter lesions, and six without WML) were treated during 12 months with monotherapy with hidrochlorotiazide 25 m,or amlodipine 10 mg or atenolol 100 mg. At baseline and at the end of treatment, BPV was measured with the continuous noinvasive finger monitoring device. The following parameters were analyzed: 24-h average systolic(S), and diastolic(D) long-term BP variability(LTBPV)and systolic and diastolic short-term BP variability (STBPV) as well as systolic and diastolic blood pressure (BP).