Background:Menopause is an independent risk factor in metabolic syndrome which induced an alteration of the lipid metabolism by hormonal changes. Apolipoprotein A5 gene (APOA5) was related to the regulation of triglyceride and high density lipoprotein cholesterol (HDL-C) level with biosynthesis and decomposition. This study was conducted to investigate the relationship between APOA5 polymorphism and metabolic syndrome in Korean postmenopausal women. Methods: This study included 307 postmenopausal women with anthropometric and biochemical measurement in 2010-2011. The polymorphism of APOA5 was analyzed by polymerase chain reaction-restriction fragment length polymorphism method with MseI restriction enzyme. Results: The metabolic syndrome prevalence with TT genotype was significantly lower than the frequency in those with TC/CC (27.09%, 38.46%, and 45.71% for TT, TC, and CC, respectively; P < 0.05). Multiple regression analysis of metabolic syndrome risk factors indicated that postmenopausal women with CC genotype had a higher risk with 3 times than that in TT genotype (P < 0.05). APOA5 C carriers showed an increased risk of triglyceride level (odd ratio, 2.93 and 1.85 for CC and TC+CC, respectively; P < 0.05). Interestingly, HDL-C was related to triglyceride directly in comparison to APOA5. Conclusion:The results of this study indicate that APOA5 has an influence on serum triglyceride and HDL-C, which contribute to metabolic syndrome in Korean postmenopausal women. (Endocrinol Metab 27:276-281, 2012)
Background and Objectives: Research on climacteric syndrome among middle-aged men remains scant compared to the research among women. Moreover, limited research has been conducted on climacteric syndrome among older adults living alone, a population that is growing due to accel-erated population aging, particularly research on the health interventions for older men living alone who are more vulnerable than older women living alone. This cross-sectional study inves-tigated whether the prevalence of climacteric syndrome is associated with the type of household middle-aged men live in and identified the determinants of climacteric syndrome based on the household type. Materials and Methods: We surveyed 600 middle-aged men (those aged between 40 and 64) living in multi-person households and 600 middle-aged men living alone about general characteristics and diet-related factors. Climacteric syndrome was measured using the Aging Males’ Symptoms scale. Data were analyzed using Pearson’s chi-squared test, Fisher’s exact test, and logistic regression. Results: The results showed that the risk of climacteric syndrome among middle-aged men living alone is 1.6 times higher than the risk among middle-aged men living in multi-person households (p = 0.006). In multi-person households, income and breakfast frequency were found to predict climacteric syndrome (p < 0.05), while age, breakfast frequency, dinner frequency, and weekly eating out frequency predicted climacteric syndrome in single-person households (p < 0.05). Conclusion: In single-person households, dietary factors are more closely linked to the prevalence of climacteric syndrome than in multi-person households. This result highlights the need for climacteric syndrome interventions for middle-aged men whose health concerns may persist into older adulthood.
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