Restoration of hormonal homeostasis and, as a consequence, the improvements in well-being, performance status and sexual function of the individuals has always been an indispensable aspect of anti-aging medicine. Albeit hormone replacement therapy (HRT) being the easiest and most preferred therapeutic method employed by majority of physicians, the undisputed risks associated with HRT dictate the necessity to search for alternative treatment solutions, capable of pledging nearly the same efficacy with considerably superior safety. In this regard, optimization of endogenous hormone synthesis and expression via the stimulation of hypothalamo-hypophyseal-adrenal axis with cell therapy beckons our attention as biological doctors. The current paper offers description of treatment protocols and analysis of the outcomes of biohormonal rejuvenation and revitalization by the means of cell therapy.
Non-specific interstitial pneumonia (NSIP) is the second most common morphological and pathological pattern of interstitial lung diseases. A significant proportion of patients with interstitial lung disease (ILD) manifest autoimmune features consisting, among others, of a morphologic domain with multi-compartment involvement and specific autoantibodies, as well as association to other autoimmune pathologies, such as systemic lupus erythematous, rheumatoid arthritis and Hashimoto thyroiditis. The symptoms of non-specific interstitial include insidious onset of dyspnea and dry cough with a restrictive pattern of decreased lung function and reduced gas exchange capacity. Corticosteroids, anti-fibrotics and immunosuppressants are the classical protocol to treat the condition, but management should be carefully individualized due to the wide heterogeneity of IPAF and lack of evidence in this particular subgroup of patients. The multidisciplinary immunological approach with xenogeneic and/or autologous peptides and its derived immune extracts might be a way to induce autoimmune tolerance, based on the anergy mechanism of secretion of immunomodulatory cytokines, such as IL-10 and transforming growth factor-β (TGF-β) and T-regulatory cells. Here we report a clinical case of 47 years old woman with IPAF and organized pneumonia (OP) with rheumatic complications addressed integrativelly with the autologous Active Specific Immunotherapy (ASI), xenogeneic peptide immunotherapy, ozone autohemotherapy and nutritional antioxidants perfusion. The integrative biomedical program was run from July 2019 until February 2020 with stabilization of lung degeneration and compliances, consequent modulation of chronic inflammation, progressive reduction of dry cough and joint pain, less fatigue, better sleep quality, overall energy and further decreasing of pharmaceutical's dosage. This article opens a scientific discussion on how to address positively to chronic autoimmune conditions within the use of biomedical multifunctional and natural tools like autologous and xenogeneic immunotherapy in combination with a more conservative pharmaceutical protocol.
Cartilage diseases refer to an umbrella of joint disorders, joint injuries and cartilage tumors that are largely characterized by degenerative chondrocyte changes in joints.Osteoarthritis(OA) is the most common form of chronic cartilage diseases, affecting 250 million people and is the fourth leading cause of disability worldwide. The widely used pharmacological treatments for OA have shown limited benefits, and further studies are required. Stem cells have been proposed as regenerative cell therapy for OA to repair and replace the injured cells and tissues with new ones, due to their potential for self-renewal and differentiation into cartilage-forming chondrocytes and immune-modulating capabilities. A number of preclinical and clinical studies have confirmed the potential for mesenchymal stem cells as a novel therapeutic strategy for the treatment of OA. In this review, we look at the promising evidence for stem cell use in OA treatment.
Genome of eukaryotic cells contains up to 69% of the transposable elements and repetitive sequences. To a large extent it is a result of billions of years of evolution through which eukaryotes were encountering gazillions of viruses and storing the footprints of those encounters in its genome. This time Mankind deals with a novel virus belonging to the coronavirus family, which albeit being widely spread in the wildlife is new to humans. Once infected, 80% of humans experience a flu-like symptoms and eventually recover. However the real menace is posed to those whose vulnerability is determined by old age and underlying medical conditions. Akin to the scenario of alien invasion, this pandemic will leave a notable imprint on social, economic and biological aspects of human existence. How did it happen, or rather, why did we allow this to happen? Let’s ponder over the biological, medical and philosophical domains of COVID19 pandemic.
Autologous Active Specific Immunotherapy (AASI) is a type of immunotherapy that targets complementary autoantibodies which suppress the specific immune response using anti-idiotypic antibodies. AASI entails removing immune cells (dendritic cells) from the patient's blood and subjecting them in a lab setting to a particular tumour antigen (proteins detected on the surface of cancer cells). AASI is a personalized treatment approach that has been used to treat various types of cancer, including melanoma, osteosarcoma and breast cancer. Clinical trials have shown promising results, with some patients experiencing complete remission or long-term disease control. Although AASI has shown potential as a cancer treatment, further research is needed to optimize its effectiveness and safety. AASI is a complex and expensive therapy, and its use is currently limited to specialized cancer treatment centres.
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