Objective: The paper presents the results of clinical trials of medications based on S-amlodipine and S/R-amlodipine. Materials and methods: A total of 140 patients diagnosed with arterial hypertension of I and II degree were included into study, in particular, 70 patients with 1st degree and another 70 patients with 2nd degree hypertensive disease. A group consisted of 80 male (57%) and 60 female patients (43%) aged from 45 to 73 years. The average age of the examined patients was 62.1±5.8 years. Duration of the disease was established between 1 and 22 years (12.5±1.2 years on average). Results and discussion: The stereoselectivity mechanisms of the studied amlodipine enantiomers were found to initiate the activity of only one S-amlodipine isomer. Applying S-amlodipine in treatment was proved to improve significantly the clinical results, facilitate the course of hypertensive disease, and normalize the structure and functional heart condition. After 8 weeks of amlodipine-based treatment, the diastolic pressure in groups receiving S-amlodipine reduced by 20-25% and systolic pressure reduction was between 20% and 31%. Among patients taking the original amlodipine medication consisting of S and R enantiomers, the diastolic pressure decrease was between 19.4% and 24%, and the systolic pressure reduced from 16.7% to 27.37%. Conclusions: By using S-amlodipine, the prescribed medication dosage can be reduced by 50%, which allows diminishing the drug load on the body and lessen the side effects. Bangladesh Journal of Medical Science Vol.20(2) 2021 p.439-448
The decade of Education for Sustainable Development (ESD), which has been declared by United Nations, is ending in 2014. That is while the preliminary results should be summarized, and this area’s prospects should be defined. In this paper the essence of ESD, in which several trends (adaptation, formalization, modernization, reformation and transformation) are emphasized from viewpoint of their content has been considered. The ESD’s main psychopedagogical and socio-ecological characteristics have been generalized. It has been demonstrated that there is no the ESD’s universal model. The results of Russian initiatives’ monitoring in the ESD area on all levels of education (from pre-school till postgraduate) have been presented. According to poll of experts the assessment of degree of implementation related to Strategy of the United Nations’ European Economic Commission for ESD has been given. The pedagogical potential of ESD has been revealed as well as diffi culties related to ESD establishing in the Russian Federation.
Экологическая безопасность: состояние, проблемы, перспективы А.С. Ермаков, старший научный сотрудник, канд. биол. наук 1 Д.С. Ермаков, профессор, д-р пед. наук, канд. хим. наук 2 1 Институт экспериментальной медицины РАМН, г. Санкт-Петербург, 2 Московский институт открытого образования, г. Москва e-mail: ermakov1203@yandex.ru В Санкт-Петербурге 28-29 мая 2015 г. состоялся VII Невский международный экологический конгресс «Стратегия экологической безопасности: механизмы реализации». Конгресс проводится с 2008 г. в целях содействовать формированию международной системы экологической безопасности путем укрепления трансграничного сотрудничества, совершенствования международного экологического права и сближения законодательства государств -участников Содружества Независимых Государств, регулирующего общественные отношения в области взаимодействия общества и природы. В статье представлены основные результаты обсуждения проблем экологической безопасности России в международном контексте (включая проект Стратегии экологической безопасности Российской Федерации на период до 2025 г.), которое проходило в формате пленарного заседания и круглых столов с участием руководителей законодательных и исполнительных органов государственной власти, представителей международных организаций, деловых кругов, образовательных и научно-исследовательских учреждений, средств массовой информации из 32 стран мира и 62 регионов России. Ключевые слова: конгресс, экологическая безопасность, стратегия, механизмы реализации.in St. Petersburg. The congress has been heldsince 2008. The main goal of this congress is to assist in the development of international system of environmental safety through international collaboration, to improve international environmental law, and to coordinate the legislation of members of the Common wealth of Independent States that regulates public relations in interaction between society and nature. In this article, we present basic results of discussion of the problems of Russian environmental safetyin international context (including the project of Strategy of ecological security of the Russian Federation for the period until 2025). Members of legislative and executive branches of the government, representatives of international organizations, business communities, educational and research establishments, mass media from 32 countries and 62 regions of Russia discussed issues during the plenary session and round tables.
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