A one-pot multicomponent green and environmentally friendly synthesis of 5-amino-3-benzothiazol-2-yl-7-(phenyl)-2-phenyl-2,3-dihydro-thiazolo[4,5-b]pyridine-6-carbonitrile via Knoevenagel condensation followed by Michael addition has been described in the presence of a green, low-cost, mild, and efficient magnesium oxide as the heterogeneous base catalyst. The present methodology has attractive features such as excellent product yields, environmentally benign milder reaction conditions, use of nontoxic organic solvents, and easily recoverable and reusable nanocatalyst. The synthesized compounds have been confirmed by spectral analysis (Fourier transform infrared, 1 H-NMR, 13 C-NMR, and mass spectrometry).Scheme 2. Synthesis of 5-amino-3-benzothiazol-2-yl-7-(phenyl)-2-phenyl-2,3-dihydro-thiazolo[4,5-b]pyridine-6-carbonitrile derivatives.Scheme 3. Plausible mechanistic pathway of reaction.
A detailed investigation has been carried out on thiazoles and its derivatives to judge its efficacy to overcome several CNS disorders. This article covers the recent updates of thiazole and its derivative with CNS activity already present in literature and will definitely provide a better platform for the production and development of potent thiazole based CNS vigorous drugs in near future.
An efficient, green and environmentally friendly grindstone method for the synthesis of 2-arylbenzothiazole derivatives in the presence of urea nitrate as the catalyst under solvent-free conditions was developed. All products were characterized by elemental analysis and spectral methods.
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