Polybenzoxazines (Pbzs) are considered as an advanced class of thermosetting phenolic resins as they overcome the shortcomings associated with novolac and resole type phenolic resins. Several advantages of these materials include curing without the use of catalysts, release of non-toxic by-products during curing, molecular design flexibility, near-zero shrinkage of the cured materials, low water absorption and so on. In spite of all these advantages, the brittleness of Pbz is a knotty problem that could be solved by blending with other polymers. Chitosan (Ch), has been extensively investigated in this context, but its thermal and mechanical properties rule out its practical applications. The purpose of this work is to fabricate an entirely bio-based Pbz films by blending chitosan with benzoxazine (Bzo), which is synthesized from curcumin and furfuryl amine (curcumin-furfurylamine-based Bzo, C-fu), by making use of a benign Schiff base chemistry. FT-IR and 1H-NMR spectroscopy were used to confirm the structure of C-fu. The impact of chitosan on benzoxazine polymerization was examined using FT-IR and DSC analyses. Further evidence for synergistic interactions was provided by DSC, SEM, TGA, and tensile testing. By incorporating C-fu into Ch, Ch-grafted-poly(C-fu) films were obtained with enhanced chemical resistance and tensile strength. The bio-based polymer films produced inhibited the growth of Staphylococcus aureus and Escherichia coli, by reversible labile linkages, expanding Ch galleries, and releasing phenolic species, which was 125 times stronger than bare Ch. In addition, synthesized polybenzoxazine films [Ch/Poly(C-fu)] showed significant dose-dependent antibiofilm activity against S. aureus and E. coli as determined by confirmed by confocal laser scanning microscopy (CLSM). This study suggests that bio-based Ch-graft-polymer material provide improved anti-bacterial property and characteristics that may be considered as a possibility in the near future for wound healing and implant applications.
Background : Privileged 4H-chromenes possess the potent anticancer and anticonvulsant actives. By inspiring potency of 4H-chromenes and demands of present era of scaffold, discovery of effective molecule was carried out for the treatment of cancer and conversant. Objective : Designed and synthesized a novel series of 4H-chromene derivatives from one port synthesis for the treatment of cancer and conversant. Method : Substitution of side amide chain was formed in multiple steps on amine group of chromene. Later, anticancer activity of synthesized compounds was investigated against human colon adenocarcinoma cell line (HT-29) using sulforhodamine B (SRB) assay. Moreover, anticonvulsant activity was also screened out by using maximal electroshock seizure (MES) model and subcutaneous Metrazol Seizure Threshold Test (scMET) in albino Wistar rats. Neurotoxicity was evaluated using by rotarod test. Before the synthesis, docking studies were performed using various molecular targets. Subsequently, the computational study of the titled compounds was performed to predict the pharmacokinetic profile. Result: Among the fifteen tested compounds, A4 and A9 were found to be active against HT-29 cells (growth inhibitory dose 50% (GI50) <11µM). Moreover, compounds A4 showed the protection at 300mg/kg in scMET (h) for albino Wistar rats and compounds A9, A11, A15 exhibited the anticonvulsant effect at the doses 100, 300 and 300 mg/kg, respectively in MES screen(h). Conclusion : Due to these encouraging results, we concluded that both A4 and A9 may be effective against colon cancer. While compound A9 may be used as a considerable effective molecule for the treatment of epilepsy.
Gum katira polysaccharide is biocompatible and non-toxic, and has antioxidant, anti-microbial, and immunomodulatory properties. It is a natural polysaccharide and exudate derived from the stem bark of Cochlospermum reliogosum Linn. Additionally, it has many traditional medicinal uses as a sedative and for the treatment of jaundice, gonorrhea, syphilis, and stomach ailments. This article provides an overview of gum katira, including its extraction, separation, purification, and physiochemical properties and details of its characterization and pharmacognostic features. This paper takes an in-depth look at the synthetic methods used to modify gum katira, such as carboxymethylation and grafting triggered by free radicals. Furthermore, this review provides an overview of its industrial and phytopharmacological applications for drug delivery and heavy metal and dye removal, its biological activities, its use in food, and the potential use of gum katira derivatives and their industrial applications. We believe researchers will find this paper useful for developing techniques to modify gum katira polysaccharides to meet future demands.
A poly (methyl methacrylate-co-maleic anhydride) P(MMA-co-MA) copolymer was synthesized via radical polymerization. The synthesized P(MMA-co-MA) copolymer was identified by 1H- and 13C-nuclear magnetic resonance spectroscopy (1H-NMR), (13C-NMR), Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The poly(butylene adipate-co-terephthalate) (PBAT)/P(MMA-co-MA)–SiO2 composites were developed using a solution-casting method. The PBAT to P(MMA-co-MA) weight ratio was kept at 70:30, while the weight percentage of SiO2 nanoparticles (NPs) was varied from 0.0 to 5.0 wt.%. SiO2 was used for PBAT/P(MMA-co-MA) to solve the compatibility between PBAT and the P(MMA-co-MA) matrix. The PBAT/P(MMA-co-MA)–SiO2 composites were characterized by studied FTIR spectroscopy, XRD, SEM, and TEM. A comparison of the composite film PBAT/P(MMA-co-MA)–SiO2 (PBMS-3) with the virgin PBAT and P(MMA-co-MA) film revealed its good tensile strength (19.81 MPa). The WVTR and OTR for the PBAT/P(MMA-co-MA)–SiO2 composites were much smaller than for PBAT/P(MMA-co-MA). The PBAT/P(MMA-co-MA)–SiO2 WVTR and OTR values of the composites were 318.9 ± 2.0 (cc m−2 per 24 h) and 26.3 ± 2.5 (g m−2 per 24 h). The hydrophobicity of the PBAT/P(MMA-co-MA) blend and PBAT/P(MMA-co-MA)–SiO2 composites was strengthened by the introduction of SiO2, as measured by the water contact angle. The PBAT/P(MMA-co-MA)–SiO2 composite films showed excellent antimicrobial activity against the food-pathogenic bacteria E. coli and S. aureus from the area of inhibition. Overall, the improved packaging characteristics, such as flexibility, tensile strength, low O2 and H2O transmission rate, and good antimicrobial activities, give the PBAT/P(MMA-co-MA)–SiO2 composite film potential for use in food packaging applications.
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