Imidazo[1,2‐a]pyridine is an important nitrogen‐containing heterocycle from biological as well as pharmaceutical point of view. In recent years, regioselective functionalization of C−H bond of imidazo[1,2‐a]pyridine is extensively carried out using various transition metal‐based catalysts. Alkenylation, arylation, dual dehydrogenative annulations, formylation, thiolation, aminomethylation, dicarbonylation, phosphonylation along with other significant reactions are the progress in the field of functionalization of imidazopyridine. Most of these functionalizations are done at the C‐3 position of imidazo[1,2‐a]pyridine scaffold and in addition to that development towards C‐5 regioselectivity is also available. In this review, our aim is to present the recent advances for the functionalization of imidazo[1,2‐a]pyridine employing transition metal catalysts under significant reaction conditions.
The free radical triggered convenient synthesis of bis(indolyl) methane using various indole and aldehyde derivatives with potassium peroxodisulfate as catalyst under the ambient conditions is developed. This protocol exhibits a wide range of sterically and electronically diverse substrate scope with good to excellent yield (up to 94 %) of the desired product without affecting the bromo, chloro, iodo, nitro, methoxy, and hydroxyl groups. The experimental observation indicates that the reaction follow a radical pathway.
In organic synthesis, decarboxylation and C-H bond functionalization are two major processes. Direct C-H bond functionalization of cyclic ethers through decarboxylation by using electronically diverse cinnamic acid derivatives in presence...
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