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The paper proposes a method to measure the mean velocity of solid particles based on the spatial filtering effect of the electrostatic sensor. To determine the relationship between the spatial frequency characteristics of the sensor and solid particle velocity, a general formula is derived by analyzing quantitatively the spatial filtering characteristics of the electrostatic sensor along with the accepted assumptions. The effects of the geometric parameters of the sensor, particle velocity distribution, particle concentration distribution over the cross-section of a pneumatic pipeline, particle size, particle material type and frequency resolution on particle velocity measurement accuracy are also discussed in detail. Experiments are performed on a bench-scale gravity-fed particle flow experimental rig to test the performance of the velocity measurement system. The off-line experimental results show that the system repeatability is within ±5% over the velocity range of 2–6 m s−1 for concentrations of solid particles in the range of 0.5–6.0%.

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Since China hosted the Olympic Games in 2008, a mass of construction and demolition (C&D) wastes were produced with the rapid urbanization construction. Recycling the C&D waste into recycled aggregates (RA) is an effective method for reducing the amount of C&D wastes. Many studies on the properties of RA and the durability of recycled aggregate concrete (RAC) were conducted in China over the past decade. Due to the restrictions of various languages, some valuable studies on the durability of RAC are hard to be acquired by the scholars around the world. erefore, this paper is developed to review the studies on the durability of RAC in China, and the shrinkage behavior, chloride permeability, carbonation behavior, and freeze-thaw resistance of RAC are, respectively, introduced. Considering the waste concrete, bricks, and ceramics used in preparing RA are frequently mixed together in China, this study proposes an index of average water absorption rate to quantify the effects of RA types, quality, and replacement percentages on the durability of RAC. Meanwhile, the relationship between the average water absorption rate of RA and the durability parameters of RAC is established. Finally, the improving methods of RAC durability are introduced, and the RA particle shaping and carbonation modification are emphasized.

Human microbiota influence the response of malignancies to treatment with immune checkpoint blockade; however, their impact on other forms of immunotherapy is poorly understood. This study explored the effect of blood microbiota on clinical efficacy, represented by progression-free survival (PFS) and overall survival (OS), of combined chemotherapy and adoptive cellular therapy (ACT) in advanced colon cancer patients. Plasma was collected from colorectal cancer patients (CRC) treated with either chemotherapy alone (oxaliplatin and capecitabine) (XELOX CT alone group, n = 19), or ACT with a mixed dendritic cell/cytokine-induced killer cell product (DC-CIK) + XELOX (ICT group, n = 20). Circulating microbiota analysis was performed by PCR amplification and next-generation sequencing of variable regions V3~V4 of bacterial 16S rRNA genes. The association of the blood microbial diversity with clinical response to the therapy as measured by RECIST1.1 and OS was evaluated. The baseline Chao index of blood microbial diversity predicted prolonged PFS and OS of DC/CIK immunotherapy. More diverse blood microbiota that included Bifidobacterium, Lactobacillus , and Enterococcus were identified among responders to DC/CIK compared with non-responders. The plasma bacterial DNA copy number is inversely correlated with the CD3 − /CD16 + /CD56 + NK cells in circulation and decreased following DC-CIK; however, the Chao index of plasma microbiota significantly increased after administration of the DC-CIK product and this subsequent change was correlated with the number of CD3 − /CD16 + /CD56 + and CD8 + /CD28 + cells infused. The diversity of the blood microbiome is a promising predictive marker for clinical responses to chemotherapy combined with DC-CIK. Cellular immunotherapy can affect the plasma microbiota’s diversity in a manner favorable to clinical responses.

Lactobacillus rhamnosus hsryfm 1301 possesses a stress-inducible defense system against oxidative stress, and the cross-adaptation to different stresses is a promising target to increase the stress tolerance of L. rhamnosus hsryfm 1301 during probiotic food and starter culture production.