SUMMARY UK-9040, a derivative of the antihistamine triprolidine, is a potent gastric secretory inhibitor. Given orally to dogs it reduced gastric acid, pepsin, and volume output in response to food, insulin, histamine, N-methyl histamine, and pentagastrin. Doses of 6-36 mg/kg administered orally four to five hours before the secretagogues produced a dose-dependant and up to 100% inhibition in the outputs of innervated gastric fistula and denervated Heidenhain pouch. Inhibition was still present 24 hours after administration of UK-9040 but was absent at 48 hours. Blood pressure and pulse rate were not affected. Studies with the electron microscope revealed that the normal ultrastructural responses to gastric secretory stimulation were arrested. UK-9040 showed no cumulative effect, tolerance did not occur, and after withdrawal of the drug the physiological and morphological gastric responses of the parietal cells rapidly returned to normal.The action of histamine on the gastric parietal cell is not blocked by the classical antihistamines. Four dogs with both gastric fistulas and Heidenhain studies in Pavlov stands. Gastric secretion was pouches were trained to undergo gastric secretory collected in 15 minute fractions. Capsules of UK-9040 were given orally after the dogs had fasted 'Present address:
in our center between 01/2018 and 04/2020 were included. Patients with basal FSH >20 IU/l, AMH <0.1 and severe male factors (azoospermia with testicular biopsy) were excluded. All patients received both recombinant FSH and human menopausal gonadotropin (hMG). Cumulative live birth rate (cLBR) was the primary outcome. Secondary outcomes included: the number of MII oocytes, cumulative implantation (cIR) and usable blastulation rates. Logistic regressions were performed to assess the predictive values of FORT, FOI and OSI in cLBR and embryo culture success. For each parameter, the ability of the logistic regression models to predict embryo culture success was quantified by the area under the ROC curve (AUC). Only the significant findings related to FORT, FOI and OSI were included in the multiple logistic regression model. Linear regression models were performed between cIR, cLB, FORT, FOI and OSI. Each statistic model was adjusted for age. Concerning OR for OSI the value was multiplied *100 due to the very low value.RESULTS: 429 patients met the inclusion criteria. 298 obtained usable blastocysts after ART treatment. Age adjusted OSI was significantly associated to cLBR [OR¼17. 58 (5.48-56.41), AUC¼0.705], and cIR [beta¼30.22 (7.88), p<0.001, R2¼ 0.060]. Both, FOI and OSI were independently associated with embryo culture success [OR¼2.65 (1.36-5.13) and OR¼376.99 (35.21-4035.99), respectively, AUC¼0.793]. In the linear regression model, FOI (R2¼0.06) and OSI (R2¼0.603), as well as in multiple linear regression model (R2¼0.619), were predictive of the number MII collected (p< .001). No statistically relevant results were found to be related to the FORT index. CONCLUSIONS: Our findings suggest that the only index, among those analyzed, that predict cIR and cLBR is OSI. Both, OSI and FOI, are significantly related to the number of MII oocytes obtained and predict embryo culture success. IMPACT STATEMENT: OSI and FOI indexes can significantly predict cumulative ART outcomes in women R39 years
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