Serum Gonadotropin Levels Predict Post-Trigger Luteinizing Hormone Response in Antagonist Controlled Ovarian Hyperstimulation Cycles

Wiltshire, Ashley; Tozour, Jessica N.; Hamer, Dina; Akerman, Meredith; McCulloh, David H.; Grifo, James A.; Blakemore, Jennifer K.

doi:10.1007/s43032-022-01105-8

Cited by 1 publication

(2 citation statements)

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“…This highlights the need for concern for patients with hormone levels slightly above the traditional threshold after the GnRH-a trigger, as they might subsequently experience low numbers of embryos and adverse IVF outcomes. We observed no differences in maturation or fertilization rates among the post-trigger hormone-level groups, which was consistent with the results of other studies [ 25 , 28 ].…”

Section: Discussionsupporting

confidence: 93%

“…However, the lowest ORR observed in our study was 0.12, and the corresponding patient's LH concentration after the GnRH-a trigger was 17.24 IU/L, suggesting that the use of a fixed post-trigger hormone concentration to predict ovarian response may not be appropriate for all patients. A rise in hormone levels could theoretically be considered a measure of success triggering [ 28 ], but it is difficult to determine one universal threshold for the magnitude and peak of the rise. For instance, Shapiro et al demonstrated that the post-trigger LH levels < 52.0 IU/L were suboptimal with the risk of submaximal oocyte yield and maturity, which was obviously different from conventional practice [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Post-trigger luteinizing hormone concentration to positively predict oocyte yield in the antagonist protocol and its association with genetic variants of LHCGR

Jin,

Yang,

Zheng

et al. 2023

J Ovarian Res

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Background The concentration of human chorionic gonadotropin (hCG)/ luteinizing hormone (LH) after triggering is generally accepted as a predictor of the normal ovarian response to the trigger, but few studies have explored the distribution model of concentration and its impact on oocyte yield. Genetic variations in LHCGR, known as a receptor for hCG and LH, also play a role in oocyte maturation and retrieval. The objective of the study was to investigate the impact of concentrations of hCG/LH after triggering on oocyte yield and its association with genetic variants of LHCGR. Methods A retrospective cohort study including 372 antagonist IVF cycles, in which 205 received the recombinant hCG trigger and 167 received the gonadotropin-releasing hormone agonist (GnRH-a) trigger, was conducted. The post-trigger concentrations of hCG/LH and the LHCGR N312S (rs2293275) genotype were evaluated in patients to analyse the impact of these factors on oocyte yield. Results The oocyte retrieval rate (ORR) increased significantly among the low-, medium- and high-hCG-concentration groups (0.91 ± 0.25, 0.99 ± 0.23 and 1.08 ± 0.19, P < 0.001) and among the low-, medium- and high-LH-concentration groups (0.80 ± 0.29, 0.95 ± 0.21 and 1.07 ± 0.19, P < 0.001). The Pearson correlation coefficient between the post-trigger hCG concentration and ORR was 0.242 (P < 0.001), and that between the LH concentration and ORR was 0.454 (P < 0.001). After adjustment for confounding factors, high post-trigger LH concentrations remained associated with the significantly higher ORRs (adjusted R2 = 0.541, P < 0.001). Patients with the AG genotype of LHCGR N312S were more likely to have low post-trigger LH concentrations (46.10 IU/L versus 60.91 IU/L, P < 0.001) and a significantly lower ORR (0.85 versus 0.96, P = 0.042) than patients with the GG genotype after the GnRH-a trigger. Conclusions The post-trigger LH concentration can positively predict oocyte yield in antagonist IVF cycles, and patients with the AG genotype of LHCGR rs2293275 could have a suboptimal oocyte yield using the GnRH-a trigger.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%