Introduction:Oxcarbazepine is a carbamazepine pre-drug with less drug interactions. Its adverse effects, including hyponatremia, somnolence and ataxia, are dose dependent. Olanzapine is an atypical antipsychotic drug most commonly used to manage psychoses and symptoms of irritability and aggressive behavior. Main side effects include extrapyramidal and anticholinergic symptoms, weight gain, and hyperglycemia.Case Report:In this manuscript a case of oxcarbazepine and olanzapine intoxication is discussed. A 45-year-old woman, previously diagnosed with bipolar disorder and chronic alcoholism, was presented two hours after ingestion of 30,000mg of oxcarbazepine and 140 mg of olanzapine, combined with alcohol. She was immediately treated with gastric lavage and administration of activated charcoal. During her hospitalization she was hemodynamically and respiratory stable with no neurological signs and symptoms except for somnolence. Another side effect was hyponatremia. She was discharged from our department in stable clinical condition after being evaluated by a psychiatrist.Conclusion:Early approach is crucial for the management of drug intoxication. Late symptoms can be avoided through close monitoring of vital signs, mental status and laboratory values. Psychiatric consultation is essential for a better long-term outcome.
nonspecific signs and symptoms such as fever of unknown origin and involvement of the central nervous system and skin.Methods: This is a retrospective, single-center study of 59 patients. Only HIV-negative, immunocompetent patients with untreated IVLBCL were included. The demographics, diagnostic details, therapeutic management, and outcome in patients with untreated IVLBCL were analyzed. Results: 59 patients were identified in a PUMCH from December 2010 to February 2023. The median age at diagnosis was 58 (range 32-77). 30 (51.8%) were male. 43 patients (72.9%) had an IPI score >3 and 47 patients (79.7%) had a performance status ≥2. All patients belonged to Ann Arbor stage IV and 52(88.1%) had B symptoms. The most frequent extra-nodal locations were skin (n = 30; 50.8%), lung (n = 25; 42.4%), central nervous system (n = 24; 40.7%), and bone marrow (n = 20; 33.9%). Fever, hypoxemia, and edema were the most common presenting symptoms. Diagnosis of Keywords: aggressive B-cell non-Hodgkin lymphoma, other, late effects in lymphoma survivors No conflicts of interests pertinent to the abstract.
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