Aim: The aim of this study was to evaluate the effect of epilepsy disease and the antiepileptic treatment protocol on the mother, fetus, and newborn in pregnant women, diagnosed with epilepsy and taking antiepileptic drugs. Materials and Method: 55 pregnant women who were followed up at Sivas Cumhuriyet University Faculty of Medicine, Department of Obstetrics and Gynecology between 2015 and 2020 and diagnosed with epilepsy were included in the study. Age of pregnant women, number of pregnancies, number of births, age at diagnosis of epilepsy, body mass index (BMI), smoking during pregnancy, whether they went to neurology control before pregnancy, type of seizures during pregnancy, seizures in which trimester, and frequency, AED’s used during pregnancy and treatment protocols, folic acid use in pregnancy were evaluated. Obstetric complications that occurred during the follow-up of the pregnant women included in the study and the weeks of delivery were recorded. Newborn 1.-5. min. Early neonatal problems such as Apgar scores, fetal malformations and fetal distress were evaluated. Results: The median age was found to be 26 (17-42). The median number of pregnancies is 2 (1-8). The median of the number of births is 1 (0-6). The average age of epilepsy diagnosis of the women included in the study was 15 (3-29). Thirty-four (61.9%) of the patients had generalized and 2 (3.6%) partial seizures. 19 (34.5%) of them did not have seizures during pregnancy. The average of those who developed complications during pregnancy follow-up was 43.6%, and the average of those who did not develop was 56.4%. There is a statistical difference between the number of seizures in trimesters of pregnancy and the 1st minute Apgar score (p

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Cervical and ovarian cancer are two aggressive neoplasms for women, still with high mortality and morbidity. Among the molecules and compounds that have anticancer activity, it was studied the JG-98, a heat shock protein 70 (HSP70) inhibitor. It demonstrated inhibitory effects on the growth of neoplastic cells, mediated by the induction of apoptosis, with anti-proliferation activity on neoplastic cells via the apoptotic pathway. The authors investigated the antiproliferative effects of JG-98 on human cervical cancer HeLa and ovarian cancer SKOV-3, examined by a standard XTT assay. Apoptotic effects and oxidative status were also evaluated by flow cytometry, ELISA, and total oxidant status assays in HeLa cells, respectively. The IC50 values of JG-98 in HeLa and SKOV-3 cells were recorded as 1.79 and 2.96 μM, respectively. Flow cytometry results showed that JG-98 treatment remarkably increased the proportion of apoptotic cells at IC50 concentration. The JG-98 treatment significantly increased the proteins Bax, cleaved caspase 3, cleaved PARP, and 8-oxo-dG levels, all indicators of cellular apoptosis. These findings show that JG-98 significantly decreased cell proliferation and increased apoptosis in HeLa cells, suggesting that JG-98 has a promising anti-tumor effect in cervical and ovarian cancers.

Aim: Our aim in this study is to determine the perceptions of medical residency students studying at a university about the hospital education environment and the factors affecting it. Methods: This was a descriptive study. The population of the research consisted of specialty students studying at Sivas Cumhuriyet University. The research questionnaire was sent to the participants via text message to their personal mobile phone numbers. Informed consent was obtained from the participants on the first page of the survey link sent to them. The data collection tool used in the study included a total of 71 questions. The first part was created by the researchers through literature review and included 31 questions. The other 40 questions were Postgraduate Hospital Educational Environment Measure (PHEEM). Results: 266 of the 387 residency students in the faculty participated in the survey (Response rate: 68.7%). 79% of residency students studying in medical sciences and 56% in surgical sciences participated in the research. 11.7% (n=23) of residents from medical sciences and 28.6% (n=20) of residents from surgical sciences stated that no seminar hours were held. Postgraduate Hospital Educational Environment Measure mean score of the residency students was found to be 83.6 ± 25.5. The mean score did not differ significantly between departments (p=0.578). Those who thought that there were enough residents and faculty members had higher educational environment measure scores (respectively p=0.010 and p