Gebeli̇kte Epi̇lepsi̇ Ve Anti̇epi̇lepti̇k Tedavi̇ni̇n Anne Ve Yeni̇doğan Üzeri̇ne Etki̇si̇

Abstract

Aim: The aim of this study was to evaluate the effect of epilepsy disease and the antiepileptic treatment protocol on the mother, fetus, and newborn in pregnant women, diagnosed with epilepsy and taking antiepileptic drugs.
 Materials and Method: 55 pregnant women who were followed up at Sivas Cumhuriyet University Faculty of Medicine, Department of Obstetrics and Gynecology between 2015 and 2020 and diagnosed with epilepsy were included in the study. Age of pregnant women, number of pregnancies, number of births, age at diagnosis of epilepsy, body mass index (BMI), smoking during pregnancy, whether they went to neurology control before pregnancy, type of seizures during pregnancy, seizures in which trimester, and frequency, AED’s used during pregnancy and treatment protocols, folic acid use in pregnancy were evaluated. Obstetric complications that occurred during the follow-up of the pregnant women included in the study and the weeks of delivery were recorded. Newborn 1.-5. min. Early neonatal problems such as Apgar scores, fetal malformations and fetal distress were evaluated.
 Results: The median age was found to be 26 (17-42). The median number of pregnancies is 2 (1-8). The median of the number of births is 1 (0-6). The average age of epilepsy diagnosis of the women included in the study was 15 (3-29). Thirty-four (61.9%) of the patients had generalized and 2 (3.6%) partial seizures. 19 (34.5%) of them did not have seizures during pregnancy. The average of those who developed complications during pregnancy follow-up was 43.6%, and the average of those who did not develop was 56.4%. There is a statistical difference between the number of seizures in trimesters of pregnancy and the 1st minute Apgar score (p

The effects of sugammadex on pentylenetetrazole-induced seizures in mice

“…In seizures, excessive and abnormal electrical discharge from cortical neurons causes a temporary brain dysfunction (Karademir et al 2019). Epilepsy is an abnormal central nervous system condition characterized by recurrent seizures related to a genetic predisposition or pathological disorders (Tastemur et al 2020; Karademir et al 2022). About 1% of the world's population suffers from this neurological disorder (Sevki Taskıran et al 2018).…”