This study reports the fabrication of polymeric matrices through electrospinning using polymethyl methacrylate (PMMA) and poly(lactic-co-glycolic acid) (PLGA), biocompatible polymers commonly used in medical systems. These polymers were combined with an antibacterial drug, sulfadiazine sodium salt (SDS) or its supramolecular system formed with hydroxypropyl-β-cyclodextrin (HPβ/CD) at 1:1 molar ratio, aiming to assemble a transdermal drug delivery system. The formation of fibers was confirmed by scanning electron microscopy (SEM), and the fibers’ surface properties were analyzed using contact angle and water vapor permeability techniques. Drug release tests and cell viability assays were performed to evaluate the potential toxicity of the material. SEM images demonstrated that the obtained fibers had nanoscale- and micrometer-scale diameters in PLGA and PMMA systems, respectively. The contact angle analyses indicated that, even in the presence of hydrophilic molecules (SDS and HPβCD), PMMA fibers exhibited hydrophobic characteristics, while PLGA fibers exhibited hydrophilic surface properties. These data were also confirmed by water vapor permeability analysis. The drug release profiles demonstrated a greater release of SDS in the PLGA system. Moreover, the presence of HPβCD improved the drug release in both polymeric systems and the cell viability in the PMMA SDS/HPβCD system. In terms of antibacterial activity, all membranes yielded positive outcomes; nevertheless, the PLGA SDS/HPβCD membrane exhibited the most remarkable results, with the lowest microbial load values. Additionally, the pseudo wound healing analysis demonstrated that the PLGA SDS/HPβCD fiber exhibited results similar to the control group. Consequently, these findings exemplify the substantial potential of the obtained materials for use in wound healing applications.
No abstract
Objetivo: Revisar evidências atuais acerca da aplicação e dos benefícios da Eletroconvulsoterapia (ECT) em pacientes com transtorno afetivo bipolar. Revisão bibliográfica: Os mecanismos de ação da ECT no tratamento da bipolaridade não são totalmente elucidados e essa prática é comumente desacreditada pela própria comunidade médica, gerando descrenças quanto a sua efetividade e segurança. Todavia, há fortes correlações com o uso da terapia e a melhora significativa dos sintomas depressivos, maníacos e de estados mistos no transtorno bipolar. A taxa de resposta é, no geral, igualmente eficaz, ou superior à mediação habitual, variando conforme grupos específicos ou complexidade do quadro. A ECT é capaz, também, de reduzir a ocorrência de oscilações de humor, sendo eficaz, também, como terapia de manutenção. Uma maior resposta demonstra estar atrelada a diversos fatores, como maior velocidade da onda da ECT, posicionamento unilateral de eletrodos e idade avançada. Considerações finais: Apesar dos efeitos benéficos, a ECT não está isenta de colaterais. Mais estudos devem ser propostos para elaboração de diretrizes mais assertivas sobre o tema.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.