Many studies have shown that subclinical ketosis (SCK) is associated with an increased risk of developing various diseases, reproductive disorders, and changes in milk production. The present work aims at producing an overview between this disorder and theses outcomes. A meta-analysis of the literature, including 131 different models from 23 papers, or a review when the literature was scarce was conducted. For each outcome, the odds ratio (OR), relative risk, or hazard ratio was presented for various moderators to reduce heterogeneity among the studies. The raw change in milk production associated with SCK was estimated and adjusted, taking into consideration the outcomes known to interact with milk production during the peripartum period. The results showed that 2 main categories of moderators had a significant effect on the adjusted risk. First, the adjustment made by defining SCK as (1) β-hydroxybutyrate concentration >1.4 mM, (2) nonesterified fatty acid (NEFA) concentration >0.4 mM prepartum, or (3) NEFA concentration >1.0 mM postpartum corrected the underestimated risk (despite low significance). This is because several trials reported the relevant risks using lower thresholds for the β-hydroxybutyrate or NEFA values. Using a low threshold leads to lower risk of disease compared with using a high threshold. Second, the correction produced using the polyfactorial terms corrected the overestimation of risk because many trials reported only univariable models. The relative risk or OR (95% confidence interval) related to abomasal displacement, clinical ketosis, early culling and death, metritis, placental retention, clinical mastitis, lameness, and a doubling of the SCC in cases with SCK were 3.33 (2.60-4.25), 5.38 (3.27-8.83), 1.92 (1.60-2.30), 1.75 (1.54-2.01), 1.52 (1.20-1.93), 1.61 (1.24-2.09), 2.01(1.64-2.44), and 1.42 (1.26-1.60), respectively. The precision level of the estimate depended on the outcome. The direct mean ± standard deviation of the 305-d milk losses associated with SCK were 251 ± 73 kg after adjusting for abomasal displacement, clinical ketosis, metritis, and placental retention. The OR (95% confidence interval) for first service calving risk in cases of SCK was 0.67 (0.53-0.83). The calving-to-first-service interval was 8 d longer and the calving-to-conception interval was 16 to 22 d longer in cows with SCK. The relationships among the different reproductive indicators were quantified in only 1 or 2 trials. The present work highlights the need to conduct further studies on the associations between SCK and the risks of diseases, changes in milk production, and reproductive parameters.

Low colostrum intake at birth results in the failure of passive transfer (FPT) due to the inadequate ingestion of colostral immunoglobulins (Ig). FPT is associated with an increased risk of mortality and decreased health and longevity. Despite the known management practices associated with low FPT, it remains an important issue in the field. Neither a quantitative analysis of FPT consequences nor an assessment of its total cost are available. To address this point, a meta-analysis on the adjusted associations between FPT and its outcomes was first performed. Then, the total costs of FPT in European systems were calculated using a stochastic method with adjusted values as the input parameters. The adjusted risks (and 95% confidence intervals) for mortality, bovine respiratory disease, diarrhoea and overall morbidity in the case of FPT were 2.12 (1.43–3.13), 1.75 (1.50–2.03), 1.51 (1.05–2.17) and 1.91 (1.63–2.24), respectively. The mean (and 95% prediction interval) total costs per calf with FPT were estimated to be €60 (€10–109) and €80 (€20–139) for dairy and beef, respectively. As a result of the double-step stochastic method, the proposed economic estimation constitutes the first estimate available for FPT. The results are presented in a way that facilitates their use in the field and, with limited effort, combines the cost of each contributor to increase the applicability of the economic assessment to the situations farm-advisors may face. The present economic estimates are also an important tool to evaluate the profitability of measures that aim to improve colostrum intake and FPT prevention.

Dairy calf and replacement heifer mortality in France was assessed by calculating mortality rates at 0 to 2d (calves), 3d to 1 mo (calves and heifers), 1 to 6 mo of age, and 6 mo of age to first calving (heifers) using the national identification database. Between birth and 2-d-old, 261,000 and 251,000 of the 3.56 and 3.43 million calves born in 2005 and 2006, respectively, died. The overall 0- to 2-d-old calf mortality rate was around 6.7%, which is similar to the low range of values reported in the literature. Among the 2.38 and 2.39 million calf-month, 139,000 and 133,000 died between 3d and 1 mo of age in 2005 and 2006, respectively. Among the 3d to 1 m of age group, dairy calf mortality rate was around 5.7%. Such a rate has not been reported previously because of the great differences in age classes between studies. For the 0- to 2-d-old and 3-d- to 1-mo-old calves, annual mortality was zero on 26 and 44% of the farms, respectively. Calf mortality during the first month of life increased in winter (to 12-17%) and decreased in summer (to 8-12%), with a small peak in June or July. Mortality during the first month of life is higher in males than in females, with a mortality odds ratio of 1.20 (and 95% confidence interval of 1.19-1.21). Such a difference is also found within the noncrossed or beef-crossed calf subpopulations. Disregarding the sex, the mortality of beef-crossed calves is slightly less than that of noncrossed dairy calves, with a mortality odds ratio of 0.98 (and 95% confidence interval of 0.98-0.99) before 1 mo of age. In heifers, around 51,000, 35,000, and 40,900 out of the 1.2 million 3-d- to 1-mo-old, 1.1 million 1- to 6-mo-old, and 950,000 6-mo-old to first calving heifers died, respectively. The respective mortality rates were 4.5, 3.1, and 4.1%; these rates are similar to the low range of values previously published. The proportions of farms with no heifer mortality during a year were higher than for calves, between 60 and 70%. The mortality probability for heifers was very high for the first day of life (95% survival between 2-30 d of age), then decreased during the first year of life and became constant up to around 3 yr of age (88% survival at 36 mo of age). The risk of mortality is higher in Montbéliarde and Normande heifers compared with Holstein. In conclusion, and beyond the average mortality rates, farmers and farm advisors should keep in mind the broad range of mortality values, which shows that very low mortality (1-2%) can be achieved, even in animals with a known high risk of mortality, such as beef-crossed dairy calves.