Angioma serpiginosum is a rare benign vascular disorder, characterized clinically by multiple minute, red to purple, grouped macules in serpiginous and gyrate patterns and histopathologically by ectatic dilatation of capillaries. Patients can undergo unnecessary hematological tests, because the condition can be confused with chronic purpuric dermatoses. An 18-year-old man with angioma serpiginosum of his left arm was evaluated by dermoscopy and treated with pulsed dye laser. Numerous small, relatively well-demarcated, round to oval red lagoons were determined with dermoscopy, and approximately 75% of the area of his lesion disappeared after four sessions of pulsed dye laser. Our case supports the hypothesis that dermoscopy is beneficial in the diagnosis of angioma serpiginosum and that pulsed dye laser is effective in the treatment of this disorder.
Acantholytic dyskeratosis is a distinct histological pattern characterized by hyperkeratotic and parakeratotic epidermis with intraepidermal clefts harbouring acantholytic and dyskeratotic keratinocytes. This histopathological pattern is uncommon in dermatoses of the anogenital region. We report a 30-year-old woman who had numerous smooth whitish papules on the labia majora, perineum and perianal region, which coalesced into plaques in some areas. Microscopically, the lesions showed prominent suprabasal and intraspinous acantholysis with dyskeratotic keratinocytes. Direct immunofluorescence examination revealed intercellular Ig G and C(3) within the epidermis. We were unable to find a similar case of papular acantholytic dyskeratosis of the anogenital area with positive direct immunofluorescence findings reported in the literature, thus in this report, the clinicopathological features of a unique case are presented.
Various studies have shown the blocking effects of topical agents on UVB penetration, which can be used in combination with phototherapy. In this study, the photoprotective effects of 0.005% calcipotriol, 0.05% clobetasol-17-propionate, and 0.1% tretinoin, which can be used in combination with broad-band UVB, were investigated in an in vivo test. In a study group of 20 patients, phototests were performed to determine minimal erythema doses (MED) and the tests were repeated with thin (0.1 cc/25 cm2) and thick (0.3 cc/25 cm2) calcipotriol, clobetasol-17-propionate, and tretinoin in cream forms and sunscreen. After determining the MED, the test was repeated in another 20 patients with thin and thick calcipotriol and clobetasol-17-propionate in both cream and ointment forms and sunscreen. MED was increased with thin and thick applications of all agents. Moreover, the photoprotective effects of each agent increased with their thick applications compared with thin ones. The application of calcipotriol cream and ointment, clobetasol cream and ointment, and tretinoin cream, all of which can block UVB, is not recommended just before phototherapy.
ÖzetAmaç: Behçet Hastalığı mukokutanöz sistem, göz, kardiyovasküler sistem, böbrek, akciğer, eklem ve merkezi sinir sistemi tutulumu ile seyredebilen multisistemik bir hastalıktır. Behçet Hastalığında gastrointestinal sistem tutulumu nadirdir. Bu çalışmada mide boşalma sintigrafisi ile Behçet Hastaların-da mide boşalma oranlarının araştırılması amaçlandı. Gereç ve Yöntem: Solid mide boşalma oranlarının tesbiti amacıyla 14 Behçet Hastası ile 14 sağlık-lı kontrol grubu sintigrafik olarak incelendi. Bir gece açlıktan sonra tüm olgular Tc-99m DTPA ile işaretli yumurta ve kızarmış beyaz ekmekten oluşan solid gıda aldı. Yemek yenilmesinden hemen sonra olgular gamma kamera altı-na sırt üstü yatırıldı ve 90 dakika boyunca sürekli görüntüler alındı. Mide yarı boşalma zamanı (T ½) ve 60. dakikada midede kalan radyoaktif madde oranı hesaplandı. Bulgular: Behçet Hastalarının ortalama yaşı 41.00±10.25, kontrol grubunun ise 40.57±10.05 idi. Behçet Hastalarının T ½ değeri 85± 61 dakika olarak bulunurken kontrol vakalarında 63±22 dakika olarak bulundu (p=0.122). 60. dakikada midede kalan radyoaktif madde oranı Behçet Hastalarında ve kontrol vakalarında sırasıyla % 69.3 ± 14.0 ve % 54.6± 22.0 idi (p=0.035). Tartışma: Mide yarı boşalma zamanları arasında belirgin bir farklılık olmamasına rağmen 60. dakikada midede kalan radyoaktif madde oranı Behçet Hastalarında kontrol grubuna göre belirgin yüksekti. Sonuç olarak gastrik staz Behçet Hastalarında multisistemik tutulum sonucu görülebilir. Anahtar KelimelerBehçet Hastalığı; Mide Boşalma; Gastrik Staz; Sintigrafi Abstract Aim: Behcet's disease is a multisystemic disease that includes the mucocutaneous, ocular, cardiovascular, renal, pulmonary, joint and central nervous system involvement. Gastrointestinal system involvement is rare in Behcet's disease. Current study was planned to investigate the rate of gastric emptying in patients with Behcet's disease by using gastric emptying scintigraphy. Material and Method: In order to determine gastric emptying rate of solids, 14 patients with Behcet's disease and 14 healthy controls were studied scintigraphically. After an overnight fast, all subjects ingested a Tc-99m DTPA labeled solid meal consisted of an egg and toasted white bread. Immediately after ingestion of the meal, subjects were positioned supine under the gamma camera and serial images were recorded continuously for 90 minutes. Half empyting time (t 1/2) and percentage of radioactive material remaining in the stomach at 60 min. were calculated. Results: The mean ages of Behcet's patients was 41.00±10.25 years and 40.57±10.05 years in control group. T ½ of Behçet's patients was found 85± 61 min. and 63±22 min. in control cases (p=0.122). Percentage of radioactive material remaining in the stomach at 60 min. was 69.3± 14.0 % and 54.6± 22.0 % in Behcet's patients and controls, respectively (p=0.035). Discussion: Although there was not a significant difference between half gastric emptying times, we determined that percentage of radioactive material remaining in the stomach at 60 m...
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