AQP1-immunoexpression had a good correlation with high-grade tumors. AQP-upregulation in perilesional areas of high-grade tumors suggests its role in vasogenic edema. Further studies involving other AQP molecules, vascular endothelial growth factor (VEGF) and hypoxia inducible factor-1 α (HIF-1α) should be undertaken to evaluate its possible role as a potential surrogate marker of high-grade tumors heralding poor outcome, inhibition of which may serve as the basis for future targeted therapy.
Mean linear melanocyte density and the ratio of melanocytes to keratinocytes is increased in cases with periorbital hyperpigmentation. It is, therefore, likely that increased melanocyte density may be the key factor in the pathogenesis of periorbital hyperpigmentation.
Properties of plasma sheath boundary in multicomponent plasma with negative ions have been investigated experimentally. The modified Bohm sheath criterion derived for thermal electron-thermal negative ion-cold positive ion model predicts the decrease of positive ion drift speed toward the sheath when the negative ion concentration is gradually increased. This modified Bohm criterion has been discussed in this experimental investigation. The experimental parameters (e.g. discharge voltage, discharge current) set for argon plasma production are kept floating during the addition of SF 6 gas. Two important effects caused by the presence of negative ions, e.g. decrease in Bohm speed of positive ions toward the sheath and reduction in plasma density have been observed. The reduction in the ion flux toward the sheath therefore causes the expansion of the sheath. The numerical solution of Poisson's equation, which includes the contribution of negative ions, is compared with the experimental findings.
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