Carboxylated poly(vinyl alcohol)
(PVA-COOH) is prepared by modifying
PVA with succinic anhydride. Then, poly(hexamethylene guanidine (PHMG)
as a cross-linker and gallic acid (GA) as an antioxidant are added
to obtain PVA-based composite hydrogel films (PVA-COOH-PHMG/GA). The
as-prepared PVA-based composite films show hydrophilic surfaces, high
swelling ratios of 600–700%, low water solubility for PVA-COOH-PHMG
samples (about 10%), and good mechanical properties. Importantly,
when the initial bacterial concentration is 107 CFU/mL,
the antibacterial rate of PVA-based composite films against Escherichia coli and Staphylococcus
aureus can reach 99.999%. When the initial bacterial
concentration is 108 CFU/mL, the antibacterial rates of
these composite films against E. coli and S. aureus can be 99.9999% and
99.988%, respectively. The antibacterial mechanism is also discussed
via a live/dead bacteria assay. The cytotoxicity test reveals that
the resultant PVA-COOH-PHMG composite hydrogel films without GA have
good biocompatibility toward L929 cells, but PVA-COOH-PHMG/GA composite
films with addition of GA decrease the cell viability. Interestingly,
the PVA-COOH-PHMG/GA composite hydrogel films can scavenge 70% of
1,1-diphenyl-2-picryhydrazyl (DPPH) free radical because of the release
of GA, indicating an excellent antioxidant efficiency. It is anticipated
that the resultant PVA-based composite hydrogel films with an adequate
amount of GA not only possess excellent antibacterial properties but
also exhibit a good antioxidant activity. Therefore, they show potential
for biomedical field applications as wound dressings.
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