Background: Sickle cell anemia is a common genetic disease in the world that results from a genetic mutation in a single amino acid base in the beta chain involved in the composition of hemoglobin, where the appearance of sickle hemoglobin Hbs as a result of replacement (β6Glu>Val) leads to changes in the structure of normal hemoglobin HbA. Aim of the study: Is to evaluate the demographic parameters levels in sickle cell anemia condition of patients with sickle cell anemia in the governorates Al-Diwaniyah and Al-Najaf Al-Ashraf. Methods: Patients with sickle cell anemia (n=84) 48 males and 36 females were on follow up in the Al-Diwaniyah and Al-Najaf Center for Hereditary Blood Disease, Iraq. The healthy persons (n=40) 20 males and 20 females as controls. Conclusion: The results showed that was no significant difference in the frequency distribution of patients and control subjects according to gender, a significant difference in the frequency distribution of patients and control subjects according to age, a significant difference in the frequency distribution of patients and control subjects according to body weight, and a significant difference in the frequency distribution of patients and control subjects according to parent consanguinity.
Background: Sickle cell anemia a dangerous genetic disorder in which the erythrocytes of the body caused by a mutation in the HBB gene in the sixth position of the β chain, there is a change in the composition of hemoglobin due to the presence of sickle hemoglobin (Hbs). Aim of the study: Is to evaluate the hematological parameters levels in sickle cell anemia condition of patients with sickle cell anemia in the governorates Al- Diwaniyah and Al-Najaf Al-Ashraf. Methods: A total of one hundred and twenty-four subjects were recruited for this study which consists of eighty four sickle cell anemia subjects who (48 males and 36 females) and Forty healthy (20 male and 20 female) subjects as control who matched by age and sex of the patients groups. Conclusion: The outcomes indicated decrease in the level of RBC, Hb, MPV and HCT, while observed increased in the level of WBC, PLT, RDW-SD, RDW-CD, MCV, MCHC and PDW in sickle cell anemia patients compared with the control groups, however observed no significant in level of MCH in sickled patients compared with the control groups.
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