demographic study of sickle cell anemia patients in Al-Diwaniyah and Al-Najaf governorates

Abstract

Background: Sickle cell anemia is a common genetic disease in the world that results from a genetic mutation in a single amino acid base in the beta chain involved in the composition of hemoglobin, where the appearance of sickle hemoglobin Hbs as a result of replacement (β6Glu>Val) leads to changes in the structure of normal hemoglobin HbA. Aim of the study: Is to evaluate the demographic parameters levels in sickle cell anemia condition of patients with sickle cell anemia in the governorates Al-Diwaniyah and Al-Najaf Al-Ashraf. Methods: Patients with sickle cell anemia (n=84) 48 males and 36 females were on follow up in the Al-Diwaniyah and Al-Najaf Center for Hereditary Blood Disease, Iraq. The healthy persons (n=40) 20 males and 20 females as controls. Conclusion: The results showed that was no significant difference in the frequency distribution of patients and control subjects according to gender, a significant difference in the frequency distribution of patients and control subjects according to age, a significant difference in the frequency distribution of patients and control subjects according to body weight, and a significant difference in the frequency distribution of patients and control subjects according to parent consanguinity.