Background: COVID-19 (coronavirus disease 2019) has become a global public health emergency since patients were first detected in Wuhan, China, in December 2019. Currently, there are no satisfying antiviral medications and vaccines available. Case Presentation: We reported the treatment process and clinical outcome of a 48-yearold man critically ill COVID-19 patient who received transfusion of allogenic human umbilical cord mesenchymal stem cells (UC-MSCs). Conclusions: We proposed that UC-MSC transfusion might be a new option for critically ill COVID-19. Although only one case we were shown, more similar clinical cases are inquired for further evidence providing the potential effectiveness of UC-MSC treatment.
We introduce certain spherically symmetric singular Ricci solitons and study their stability under the Ricci flow from a dynamical PDE point of view. The solitons in question exist for all dimensions n + 1 ≥ 3, and all have a point singularity where the curvature blows up; their evolution under the Ricci flow is in sharp contrast to the evolution of their smooth counterparts. In particular, the family of diffeomorphisms associated with the Ricci flow "pushes away" from the singularity causing the evolving soliton to open up immediately becoming an incomplete (but non-singular) metric. In the second part of this paper we study the local-in time stability of this dynamical evolution, under spherically symmetric perturbations of the initial soliton metric. We prove a local well-posedness result for the Ricci flow near the singular initial data, which in particular implies that the "opening up" of the singularity persists for the perturbations also.
GPS has become a very effective tool to remotely sense precipitable water vapor (PWV) information, which is important for weather forecasting and nowcasting. The number of geodetic GNSS stations set up in China has substantially increased over the last few decades. However, GPS PWV derivation requires surface pressure to calculate the precise zenith hydrostatic delay and weighted mean temperature to map the zenith wet delay to precipitable water vapor. GPS stations without collocated meteorological sensors can retrieve water vapor using standard atmosphere parameters, which lead to a decrease in accuracy. In this paper, a method of interpolating NWP reanalysis data to site locations for generating corresponding meteorological elements is explored over China. The NCEP FNL dataset provided by the NCEP (National Centers for Environmental Prediction) and over 600 observed stations from different sources was selected to assess the quality of the results. A one-year experiment was performed in our study. The types of stations selected include meteorological sites, GPS stations, radio sounding stations, and a sun photometer station. Compared with real surface measurements, the accuracy of the interpolated surface pressure and air temperature both meet the requirements of GPS PWV derivation in most areas; however, the interpolated surface air temperature exhibits lower precision than the interpolated surface pressure. At more than 96% of selected stations, PWV differences caused by the differences between the interpolation results and real measurements were less than 1.0 mm. Our study also indicates that relief amplitude exerts great influence on the accuracy of the interpolation approach. Unsatisfactory interpolation results always occurred in areas of strong relief. GPS PWV data generated from interpolated meteorological parameters are consistent with other PWV products (radio soundings, the NWP reanalysis dataset, and sun photometer PWV data). The differences between them were approximately 1~3 mm at most at our selected stations, and GPS data processing is the main factor influencing the agreement of the GPS PWV results with those of other methods.
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