1,3,5-Benzenetriphosphonic acid, H6BTP, 1,3,5-[(HO)2OP]3C6H3, was reacted hydrothermally with copper salts in the absence and presence of 4,4'-bipyridine (bpy) and 4,4'-trimethlyenedipyridine (tbpy) in a 1:1 molar ratio leading to three new organic-inorganic hybrid frameworks. Compound 1, {Cu6[C6H3(PO3)3]2(H2O)8} x 5.5 H2O, has three different copper ions that are interconnected by the highly charged [1,3,5-(PO3)3C6H3]6- anionic moieties. These moieties self-assemble through tetra-copper units to give a cagelike motif with two benzene rings parallel to each other at a distance of 3.531 A which extend along the a axis and link with a grouping of four-coordinated copper units in the b axis direction to give the cross-linked layered structure. In compound 2, Cu{C6H3[PO(OH)O]2[PO(OH)2]}(C10H8N2), the copper ions are in square pyramidal geometries and are interconnected via chelating and bridging BTP ligands into layers which are further cross-linked by bpy ligands into a pillared layered architecture. Compound 3, {Cu2C6H3[PO(OH)O]2[PO3](C13H14N2)} x 3 H2O x 0.5 HCON(CH3)2, contains tetra-copper units that are linked by BTP ligands and further linked by tbpy linkers in the c axis direction to produce a large channel-sized 3D framework.

Background and Aims: Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short-chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3 regulation.Approach and Results: We report that Lactobacillus reuteri was markedly reduced in the gut microbiota of mice with HCC, accompanied by decreased SCFA levels, especially acetate. Additionally, transplantation of fecal bacteria from wild-type mice or L. reuteri could promote an anticancer effect, elevate acetate levels, and reduce IL-17A secretion in mice with HCC.Mechanistically, acetate reduced the production of IL-17A in hepatic ILC3s by inhibiting histone deacetylase activity, increasing the acetylation of SRY

In this work, a series of hybrids of CoP/N-doped carbon hollow spheres anchored on core–shell N-doped carbon nanofibers were facilely fabricated by the electrospinning technique followed by pyrolysis and phosphorization. The as-prepared hybrids exhibited greatly enhanced bifunctional electrocatalytic activities for the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) compared to either moiety of CoP/N-doped carbon hollow spheres and core–shell N-doped carbon nanofibers. Especially, the optimum CoP/NCF-200 hybrid exhibited high performances and stabilities for OER in alkaline conditions and for HER in both acidic and alkaline electrolytes. The catalyst also exhibited excellent performance for overall water splitting as both anodic and cathodic catalysts in alkaline media. The density functional theory calculations suggest that the synergy between CoP and N dopants leads to higher catalytic activities for HER and OER and the C atoms between N atoms in the carbon layer are the catalytically active sites for the HER.

The hydrothermal syntheses, structures, and magnetic properties of the Cu(II), Co(II), and Mn(II) complexes with organophosphonic acid 1) crystallizes in the orthorhombic space group Pbca, with unit cell parameters a ) 9.4430(10) Å, b ) 9.3681(10) Å, c ) 16.0755(17) Å, V ) 1422.1(3) Å 3 , and Z ) 4. The X-ray crystallographic determination reveals copper ions in two different coordination environments that are bridged by one terminal oxygen atom to form a threedimensional framework of corner-sharing layers. Antiferromagnetic coupling between the two types of Cu units in 1 was observed at 15 K, followed by ferromagnetic ordering at 9 K. Compound Co 3 [NH 2 (CH 2 PO 3 ) 2 ] 2 (2) crystallizes in the orthorhombic space group P2 1 2 1 2 with unit cell parameters a ) 10.7346(8) Å, b ) 13.3704(10) Å, c ) 5.3699(4) Å, V ) 770.72(10) Å 3 , and Z ) 2. All Co(II) ions are in a tetrahedral environment with both ends of the ligand bound via O atoms to adjacent Co(II) ions, thus creating tetranuclear 16-membered rings. Compound Mn{[NH 2 (CH 2 PO 3 H) 2 ] 2 (H 2 O) 2 } (3) crystallizes in the monoclinic space group P2 1 / n, with unit cell parameters a ) 7.3668(11) Å, b ) 8.1540(12) Å, c ) 14.090(2) Å, β ) 103.935-(2)°, V ) 821.4(2) Å 3 , and Z ) 2. Four phosphate oxygen atoms and two water molecules are coordinated to the mononuclear octahedral Mn(II) ions. The amino groups are protonated and therefore do not coordinate to Mn(II). Compound 3 features a one-dimensional chain architecture stitched together by hydrogen bonds.