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In 2007, an outbreak of foodborne botulism occurred in Hebei province, China. An epidemiological investigation and laboratory detection studies showed that sausage contaminated by type A Clostridium botulinum caused this outbreak of food poisoning. Its clinical and epidemiological features were different from previous reports of food poisoning.

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SIGNIFICANCE: Acute idiopathic maculopathy is a rare disease with the characteristics of sudden, severe, unilateral central vision loss after a flu-like illness. The prognosis is generally good, and poor vision usually results from complications such as choroidal neovascularization or subfoveal pigment degeneration. Multimodal imaging is helpful in the diagnosis and follow-up of this disease. PURPOSE:We report a case of acute idiopathic maculopathy and present multimodal imaging results in the diagnosis of this condition.CASE REPORT: A 37-year-old Chinese woman noted a central scotoma in her right eye a day after a prodrome of flu-like symptoms. Best-corrected visual acuity of the right eye was 20/40. Multimodal imaging was performed, and a diagnosis of acute idiopathic maculopathy was made. The variable clinical appearance of acute idiopathic maculopathy on autofluorescence, near-infrared reflectance, and optical coherence tomography (OCT) was shown. The patient's vision spontaneously recovered to 20/20 two weeks after the onset of the disease, but macular sensitivity, as measured by microperimetry, did not return to normal until 1 month. Retrobulbar injection of triamcinolone was done at 3 weeks to prevent retinal pigment epithelium hyperplasia and choroidal neovascularization. Written informed consent was obtained from the patient. CONCLUSIONS: Our findings suggest that near-infrared reflectance corresponds to the change of the outer retina and retinal pigment epithelium on OCT and complements autofluorescence in the diagnosis and follow-up of acute idiopathic maculopathy. Fundus autofluorescence, near-infrared reflectance, and OCT are recommended as routine examinations in this disease.

Background: DNA repair genes play a vital role in the treatment of many cancers, and DNA repair genes can be used in breast cancer recurrence and metastasis research. We found that the expression of DNA repair genes in breast cancer patients after recurrence and metastasis is abnormal, however, the clinical predictive significance of DNA repair genes is still elusive. Methods: The nested case-control method was used in patients with breast cancer recurrence and metastasis after surgery (n=109) and patients without recurrence and metastasis after surgery (n=109). The proteins and mRNA of DNA repair genes were detected by immunohistochemistry and Real-time PCR respectively. Results: PARP1(OR=1.485, 95%CI:1.279~1.725, P<0.05), XRCC4(OR= 1.419, 95%CI:1.217~ 1.656, P<0.05) and ERCC1 (OR=1.181, 95%CI: 1.032~1.353, P<0.05) were risk factors for postoperative recurrence and metastasis of breast cancer. Therefore, we used the ROC curve to study the optimal critical values of PARP1, XRCC4, and ERCC1, combined with the comprehensive judgment of clinical experience, we can conclude that PARP1 (cutoff value = 6, Se = 75.23%, Sp = 79.82%), XRCC4 (cutoff value = 6, Se = 78.9%0, Se = 79.82%), ERCC1 (cutoff value = 3, Se = 89.91%, Sp = 47.71%), suggesting that when the PARP1 score is higher than 6 or the XRCC4 score is higher than 6 or the ERCC1 score is higher than 3, the risk of recurrence and metastasis will increases (ORPARP1 = 14.941, 95% CIPARP1: 4.004~55.758, P <0.05; ORXRCC4 = 16.740, 95% CIXRCC4: 6.433 ~ 43.560, P <0.05; ORERCC1 = 5.285, 95% CIERCC1: 1.843 ~ 15.156, P <0.05). Due to PARP1, ERCC1 and XRCC4 belong to a part of DNA repair gene system, and the three proteins are positively correlated by correlation analysis (rPARP1-ERCC1=0.317; rPAPR1-XRCC4=0.329; rERCC1-XRCC4=0.377). The combined diagnosis of the PARR1,ERCC1 and XRCC4 have greater predictive value for the risk of recurrence and metastasis of breast cancer(Se = 88.99%, Sp = 82.57%；OR = 50.914, 95% CI: 10.918, 237.417, P <0.05).Conclusions: The recurrence and metastasis of breast cancer are predictive after PARP1>6, XRCC4>6, and ERCC1>3. The combined diagnosis of the three indicators have greater predictive value for the risk of recurrence and metastasis of breast cancer.

With the increase of the number of users all over the world, computer network not only makes people's life more convenient but also brings serious security problems. UCIrusion prevention system is an emerging information security technology in the field of network security to make up for the deficiency of firewall and UCIrusion detection. It UCIegrates the advantages of firewall and UCIrusion detection system and can actively defend the protected network in real time [9]. As the bandwidth of backbone network has generally entered the gigabit era, the research and application of gigabit network UCIrusion prevention system has become one of the hot spots in the field of information security. This article make a detail for today's computer network security, and for the computer network security defense system design and key technology were discussed, to today's problems makes the corresponding solutions and put forward corresponding solutions, aims to speed up the computer network security defense system and the application of key technologies. Thus accelerate the process of computer network security system design, accelerate the design of computer network security system.

Backgroud: To study the expression of the expression of NF-κB proteins (IKKβ, p50, p65, TNF-α) and PARP1 in patients with distant metastasis and non-metastasis after Breast cancer surgery, and analyze their correlation. Their immunohistochemical scores were used to predict their effect on postoperative distant metastases in Breast cancer patients. Methods：Nested case-control study was used. Patients with distant metastasis in the Breast cancer follow-up cohort established in 2014 were selected as the metastasis group, while non-metastasis were selected as the control group. Immunohistochemical methods were used to detect the expression of NF-κB proteins (IKKβ, p50, p65, TNF-α) and PARP1 in the Breast cancer patients. ROC was used to analyze the predictive effect of these on distant metastasis after Breast cancer surgery. COX model was used to evaluate the effects of PARP1 and TNF-α on distant metastasis after Breast cancer surgery. Results: (1) PARP1 was mainly expressed in the nucleus of Breast cancer cells. IKKβ, p50, p65 and TNF-α proteins were mainly expressed in the cytoplasm. And the Immunohistochemical score of them both are significantly higher in the group of distant metastasis than non-metastasis (P<0.001).(2) PARP1 was correlated with IKKβ, p50, p65 and TNF-α proteins (P<0.001). There was a correlation between IKKβ, p50, p65 and TNF-α proteins (P<0.001). (3) ROC curve showed that PARP1>6, IKKβ>4, p65>4, p50>2, TNF-α>4 had a predictive effect on distant metastasis.(SePARP1=78.4%, SpPARP1=79.4%, AUCPARP1=0.843; SeIKKβ=51.55%, SpIKKβ=64.95%, AUCIKKβ=0.591; Sep65=88.66%, Spp65=46.39%, AUCp65=0.716; Sep50=60.82%, Spp50=69.07%, AUCp50=0.6884; SeTNF-α=64.95%, SpTNF-α=70.10%, AUCTNF-α=0.709.)(4) COX analysis showed that the high expression of PARP1 and TNF-α were risk factors for distant metastasis after Breast cancer surgery (RRPARP1=4.092, 95%CI:2.475-6.080, P<0.001),(RRTNF-α=1.825, 95%CI:1.189-2.779, P=0.006). Conclusion:(1)PARP1, IKKβ, p50, p65 and TNF-α were positively correlated with distant postoperative metastasis of Breast cancer.(2) When PARP1>6, IKKβ>4, p50>2, p65>4, TNF-α>4, it has a certain predictive effect on postoperative metastasis of Breast cancer;(3)PARP1 may regulate the effect of TNF-α on Breast cancer metastasis through NF-κB signaling pathway, providing clues for the molecular mechanism of Breast cancer metastasis.