No abstract

No abstract

In a group of 817 individuals inducted into the U.S. Army, serum uric acid concentration was measured. The values were compared with scores secured on intelligence tests used at the Army reception center. A significant but low level of positive correlation between the two sets of values was found.

Iated by Robison and Morgan9 ****from the products of yeast fermentation.The enzyme has been only partially purified and still contains the enzymes which transform glucose-6-phosphate into glucose-l-phosphate and into fructose-6-phosphate, but the most simple explanation of the chemical changes observed is the equation UDPG + glucose-6-phosphate -> UDP + trehalose phosphate (9) R.

In an earlier communication (1) an experiment was described in which the isotopic compositions of urinary creatine and creatinine excreted by a patient with progressive muscular dystrophy were studied after a feeding of glycine-N'5. It was found, that in the first few days urinary creatine was much more enriched with N'5 than was urinary creatinine, and that the isotope concentration in the creatine fell far more rapidly than did that in the creatinine. These results were taken to mean that the creatinuria, in this patient, was not a consequence of leakage of creatine out of skeletal muscle but rather represented newly formed creatine, synthesized in liver, which had failed to gain entry into muscle.The present study represents an extension of these observations on two additional patients. Essentially the same technique as previously described was utilized. In view of the fact that the "sarcosine-nitrogen" of creatine derives from glycine nitrogen in liver, as does the nitrogen of hippuric acid, it was considered of interest to compare the abundance of N15 in simultaneously excreted creatine and hippurate after feeding glycine-N'5. To facilitate hippurate isolation from urine, small amounts of sodium benzoate were administered from time to time to each subject. EXPERIMENTALClinical histories Subject T. K., a 31-year-old white male, has exhibited evidences of muscle dysfunction since the age of 4 and was diagnosed as having progressive muscular dystrophy