In an earlier communication (1) an experiment was described in which the isotopic compositions of urinary creatine and creatinine excreted by a patient with progressive muscular dystrophy were studied after a feeding of glycine-N'5. It was found, that in the first few days urinary creatine was much more enriched with N'5 than was urinary creatinine, and that the isotope concentration in the creatine fell far more rapidly than did that in the creatinine. These results were taken to mean that the creatinuria, in this patient, was not a consequence of leakage of creatine out of skeletal muscle but rather represented newly formed creatine, synthesized in liver, which had failed to gain entry into muscle.The present study represents an extension of these observations on two additional patients. Essentially the same technique as previously described was utilized. In view of the fact that the "sarcosine-nitrogen" of creatine derives from glycine nitrogen in liver, as does the nitrogen of hippuric acid, it was considered of interest to compare the abundance of N15 in simultaneously excreted creatine and hippurate after feeding glycine-N'5. To facilitate hippurate isolation from urine, small amounts of sodium benzoate were administered from time to time to each subject. EXPERIMENTALClinical histories Subject T. K., a 31-year-old white male, has exhibited evidences of muscle dysfunction since the age of 4 and was diagnosed as having progressive muscular dystrophy

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An evaluation of the comparative actions of Tromexan and dicumarol is herein reported. Five hundred fourteen patients were studied; a total experience of 6,642 days of Tromexan therapy and 5,006 days of dicumarol therapy were reviewed and analyzed. Previous reports of the more rapid initial prolongation of the prothrombin times and more rapid return to normal follows-ing cessation of therapy with Tromexan were confirmed. During adequate therapy the protection against thromboembolism was approximately equal for the two drugs. In other respects and with minor variations Tromexan and dicumarol were found to be quite comparable. The general advantages of anticoagulant therapy in the prevention of deaths and thlomiiboemlbolic (oml)lica.tionis in imyocardial infarction were comfirnmed.

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