The steady state pharmacokinetics and pharmacodynamics of metoprolol controlled release tablets 100 mg CR/ZOK, was compared with those of metoprolol conventional tablets 100 mg (CT) and atenolol 50 mg (ATL) in ten healthy Oriental men. The study was of double-blind, cross-over placebo controlled design. The three study drugs and placebo were given in a random order once daily for 4 consecutive days with 1-week wash-out between each period. Treadmill exercise tests were performed and blood samples were obtained at fixed intervals after the fourth dose of each treatment. There was less fluctuation in the plasma level-time profile after CR/ZOK than CT and ATL. Plasma concentrations were significantly higher on CR/ZOK than CT at 24 hours after dosing. The relative bioavailability of CR/ZOK to CT was 69.0%. CR/ZOK achieved relatively more uniform beta-blocking effect over the dose interval. Compared to CT and ATL, the peak effect after CR/ZOK was less pronounced and the beta-blockade after 24 hours more effective.

Objective: This study discusses strategies to overcome hypertension patient compliance to manage self-care. The purpose of the study is to provide a summary of the importance of attention to managing hypertension. Method: a review of literature relevant to hypertension, policies, and management, both pharmacological and non-pharmacological, through cross-programs or sectors. Result: This study found that the ministry of health had compiled various policies to reduce the prevalence of hypertension, including technical guidelines for its implementation, but the strategy has not yet fully reached the minimum service standard, which is because it has not fully involved the relevant cross sectors. Conclusion: Improve the coordination system by “Joint Decree” between the Ministry of Health and the Ministry of Villages, PDT and Transmigration, the Ministry of Social Affairs, Indonesian National Army, police, and NGOs to carry out activities simultaneously to the community.

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Background: Until the last decade, the incidence of hypertension has increased sharply. It has been reported that individuals with hypertension show a low level of adherence to their therapy management. Moreover, there has been no previous research evaluating individual characteristics, adherence, and barriers to medication adherence among people with hypertension at the border of Indonesia and Timor Leste.Purpose: This study aimed to identify individual characteristics, adherence, and barriers to medication adherence among hypertensive patients.Methods: A total of 112 hypertensive patients recruited using a quota sampling method at the border of Indonesia and Timor Leste participated in this cross-sectional study. Data were collected using the Hill-Bone Questionnaire to identify adherence and the Adherence Barrier Questionnaire (ABQ) to identify barriers to medication adherence. Individual characteristics were also collected. To confirm the hypertension condition at the time of data collection, measurements of blood pressure were retaken. Descriptive statistics and Chi-square analysis were used for data analysis.  Results: The average of systolic blood pressure was 163.85(18.24) mmHg, and the diastolic blood pressure was 99.30(11.57) mmHg. The Chi-square test showed that education and occupation had a significant relationship with adherence (p<0.05) and barriers to medication adherence (p=0.000). Meanwhile, other characteristics, including age, gender, and marital status, were not significantly related to adherence (p>0.05) and barriers to medication adherence (p>0.05).Conclusion: There is a relationship between education and occupation with adherence and barriers to medication adherence, but there is no relationship when viewed from such individual characteristics as age, gender, and marital status. Further research is needed to identify effective educational methods to increase the knowledge, motivation, and self-efficacy of hypertensive patients to improve blood pressure control.

Abstract   Background: Oral cryotherapy has been scientifically proven as a non-pharmacological therapy to reduce the incidence of oral mucositis. With the decline in the incidence of oral mucositis, patient’s comfort improved, the length of stay and cost of care decreases, and maximum quality of life is achieved. Aim: To determine the effectiveness of oral cryotherapy in reducing the incidence of oral mucositis in patient undergoing chemotherapy. Method: This paper used literature review. The literature search was conducted of articles published from January 2012 through February 2018 using the PubMed, Embase, Cochrane Library and Ebscohost databases on the effectiveness of oral cryotherapy in reducing oral mucositis in patients undergoing chemotherapy. Result: This search resulted in a total of 8 articles. Evidence has indicated that there is a significance effect of oral cryotherapy in reducing oral mucositis. Conclusion: Oral cryotherapy is one of technique that easy to do, inexpensive and can be tolerated by patients in general, so it can be used widely. It can be used for adults and children with solid tumors, bone marrow transplant patients and for patients with different chemotherapy regimens (single or combination regimens).     Keywords: Oral Cryotherapy, Oral Mucositis, Chemotherapy, patient’s quality of life

Telah dilakukan kajian efek samping yang terjadi dan penanganannya pada pasien TB paru yang dilakukan terhadap 55 responden pasien TB paru di Puskesmas Melong Asih dengan menggunakan instrumen berupa kuesioner.Penelitian ini merupakan penelitian survei deskriptif dan pengumpulan datanya dilakukan secara prospektif. Data yang diperoleh dianalisis dengan analisis deskriptif. Hasil penelitian menunjukkan bahwa efek samping penggunaan obat TB paru dirasakan oleh seluruh responden dengan efek samping tertinggi berupa keluhan mual dan gangguan pencernaan sebanyak 87% pada pasien intensif, dan sebanyak 77% pada pasien lanjutan. Penanganan terhadap efek samping yang dilakukan petugas TB paru pada pasien intensif adalah pemberian informasi waktu minum obat di malam hari dan pemberian vitamin B6 berturut-turut sebanyak 93% dan 73%, dan pada pasien lanjutan diketahuiberturut-turut sebanyak 95% dan 87% yang mendapat penanganan efek samping.Hasil ini menunjukkan bahwa proses penanganan telah sesuai dengan standar Pedoman Penanggulangan Tuberkulosis dari Depkes tahun 2007.

Caring as a human trait means that a nurse should have a caring personality. As a personality, caring will be an enduring characteristic and behavior; so, a caring nurse always shows caring behavior throughout his or her lifetime. Although experts have studied and applied the concept of caring, studies on the concept of a caring personality are rare. The purpose of this article is to conceptualize the meaning and significance of a caring personality among nurses providing nursing care. To achieve this, we used the Walker and Avant concept analysis approach. The attributes of a caring personality include (1) altruism, (2) emotional intelligence, (3) emotional stability, (4) personal integrity, and (5) optimism. The antecedents of these attributes are biological bases, characteristic adaptation, and learning organization. Nurses with caring personalities will have an impact on professional caring and patient satisfaction. This article presents case examples and a definition of a caring personality. This study concludes that a caring personality in a nurse is an essential foundation for the provision of professional care and satisfaction of patients in nursing care and that the nurse must have a caring personality, in order to provide high-quality, humanized healthcare.

Stroke has a deadly domino effect and is the number one cause of neurological defects in the world. Stroke patients can experience neurological deficits including cognitive impairment and disruption in fulfilling functional status reducing patient outcome. This literature review aims to identify the appropriate intervention to improve patient outcome among stroke patients. The authors conducted a literature search using several databases, namely ProQuest, EBSCO, Sage, and Science Direct from 2008 to 2018. The keywords appropriateness in the search were “stroke-patient”, “nursing intervention”, “patient outcome”. The literature search showed there are several nursing interventions for stroke patients that have an effect on increasing patient outcomes, namely intervention of dysphagia management, mobilization exercises, acupressure, cognitive enhancement, and self-management empowerment interventions. Nursing intervention given to stroke patients varies depending on the patient's response that arises as a result of a disorder related to the function of the part of the brain affected in stroke patients. Nurses through nursing interventions have a role in improving outcomes in stroke patients   Keywords: Nursing Intervention; Patient Outcome; Stroke-Patient