Objective: This study was designed to evaluate the antihypercholesterolemic effect of Elephantosus scaber on histopatology of Sprague-Dawley rat's aorta with hypercholesterolemia diet model. Design and method: This is an Experimental study with post test only control group design. Twenty-one (21) Sprague-Dawley rats of about 2–3 months old, weighing between 150–200 g body weight, were used for the study with incidental sampling. The rats were divided into three groups (3) of seven animals in each cage. First group (G1) was the normal control administered standard meal. Positive control group (G2) and Treatment group (G3) were administered with high fat diet. Administration of 400 mg/kg body weight of Elephantopus scaber extract was given to the third group in 7–11 weeks after induced by high fat diet. Termination was done after last feed administration. Aorta section was done with Hematoxylin eosin stain. Data analysis used Kruskal-wallis followed by Mann-Whitney test. Results: Proximate measurement was carried out on the Sprague-Dawley rat's aorta section with the following results: wall thickness in normal control group 85.19 ± 8.35 mm; positive control group 95.78 ± 17.64 mm and treatment group 80.50 ± 8.41 mm. Data analysis of Kruskal-Wallis was obtained P = 0.018, a > P. The results obtained from the analysis of Mann-Whitney test are significant difference between normal control group (G1) and positive control group (G2). And non-significant difference between normal control group (G1) and treatment group (G3). Conclusions: Elephantosus scaber extract has antihypercholesterolemic potential effect that could reduce atherosclerosis on histopatology of aorta section in Sprague-Dawley rats with hypercholesterolemia diet model.
Objective: This study was designed to determine the effect of African's leaf (Vernonia amygdalina) extract towards triglyceride level of Wistar rats (Rattus norvegicus) with metabolic syndrome model. Design and method: The research was laboratory experimental research using pretest- posttest control group design. It included 30 male Wistar rats that were divided into 5 groups of normal control group (KKn), positive control group (KKp), and treatment groups (KP1, KP2, KP3). KKp, KP1, KP2 and KP3 were metabolic syndrome induced, fed with high fat high fructose diet and were given with STZ- Na injection. KP1, KP2 and KP3 were given treament of ethanolic extract of Vernonia amygdalina with dosage 50 mg/KgBW, 100 mg/KgBW, and 150 mg/KgBW respectively. Metabolic syndrome induction were done with high fat high fructose diet for 31 days and injection of STZ-Na on the 28th. Treatment groups got the extract of Vernonia amygdalina for 28 days subsequent to metabolic syndrome induction. The result data of trygliceride level were analyzed using one way ANOVA and Post-Hoc Tukey. Results: There was a significant differences of trygliceride level between day 32th and 61st with p = 0.000 (p < 0,05) on all groups. Decreased level of trygliceride were showed the highest on KP3 with mean different value 28,7476 mg/dL, followed by KP1 with 23,7983 mg/dL, and KP2 with 20,8933 mg/dL. Conclusions: Extract of African's leaf (Vernonia amygdalina) has a significant effect of lowering trygliceride level.
Professionalism is very important in the medical world. Doctor professionalism includes informed consent, communication, examination procedures, and ethics. In Indonesia there are still many doctors who have not carried out professionalism properly. Doctors in Indonesia often forget little things in the examination. One of the small things is doing hand washing before and after checking the patient. This is very important for the health of patients and doctors. Another small thing is informed consent or medical action agreement that has previously been explained about the procedure of action, possible risks, benefits of actions and alternative actions. This is very important because patients have the right to approve medical actions or not. Another small thing is explaining the purpose of the examination to the patient. This is very important because the patient must know the purpose of the examination to be carried out. Another small thing is explaining the inspection procedure. This is very important because the patient must know the procedure to be examined. Another little thing is introducing the tool to patients because this includes inspection procedures. This research is expected to be able to analyze the professionalism of Dr.Novi Damayanti at Gombong I. Health Center. This type of research is qualitative research. Information that the researchers got from the direct observation to Dr.Novi at Gombong I. Health Center The data obtained was then analyzed. The results showed that in terms of professionalism, both informed consent, examination procedures, ethics and physician communication to patients in general had met the Indonesian Medical Ethics Code and Health Law. It's just that in small cases, for example hand washing and introducing tools to patients are often considered trivial so this action is not carried out, even though this is part of the inspection procedure. Suggestions for health centers and health care staff, namely do not forget small things like washing hands and introducing tools to patients because this includes inspection procedures.
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