Metabolic Syndrome (MS) may be characterized with obesity and insulin resistance. In obesity, the increased accumulation of fat in the circulation and tissues will lead to Reactive Oxygen Species (ROS), followed by oxidative stress. Nonalcoholic Fatty Liver Disease (NAFLD), the accumulation of excess free fat in the form of triglycerides caused by lipolysis due to insulin resistance, can cause inflammation and liver cells damage characterized by increased serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT). Nigella Sativa (Black Seed) oil is known to be efficacious as an antioxidant that can improve hepatic function. This study uses a cross over design to determine the effect of black seed oil with a dose of 1.5 ml/day and 3 ml/day on SGOT and SGPT activities in patients with SM. A total of 62 SM patients were divided into two groups which received 1.5 ml/day and 3 ml/day respectively for 20 days, and after 7day washout, the doses were reversed. Measurements were performed on the 21st and 49th days. The results showed a significant difference in SGOT activity decrease in patients receiving 1.5 ml/day compared with those receiving 3 ml/day. However, in terms of SGPT, there was no significant difference between the two treatment groups.
Hypertension in the elderly can increase the workload of the heart and arteries which, if continued, can cause damage to the heart and blood vessels. So that requires routine medication adherence to reduce blood pressure. While the elderly with hypertension must take medication regularly because adherence and a good understanding in carrying out therapy can affect blood pressure and prevent complications. This study aims to determine the pattern of the use of hypertension drugs in outpatient geriatric patients in kindergarten hospitals. II Pelamonia Makassar in January-March 2019. This type of research is a non-experimental quantitative study using descriptive design. Descriptive research that aims to make a systematic, factual, and accurate description of the facts and the nature of a particular population or area. This study obtained 23 medical records of geriatric patients who met the inclusion criteria. The inclusion criteria in this study were geriatric patients diagnosed with hypertension with age usia 60 years and receiving hypertension treatment. The results showed that the most commonly used classes of hypertension were amlodipine by 23%, single candesartan by 17%, and micardis by a single 13%, and the most used drug combination therapy was a combination of amlodipine and candesartan by 17%, amlodipine and valsartan by 13%), while candesartan and bisoprolol by 17%.
ABSTRAK Penelitian ini bertujuan untuk mengetahui efektivitas penurunan kadar glukosa darah dari rebusan daun pandan wangi (Pandanus amaryllifolius Roxb.) pada mencit yang telah di induksi glukosa 20% b/v. Penelitian ini dibagi menjadi 5 kelompok perlakuan, kelompok I kontrol negatif dengan pemberian Na-CMC 0,5% b/v, kelompok II pemberian glibenklamid 0,002% b/v sebagai kontrol positif, kelompok III pemberian rebusan daun pandan wangi dengan konsentrasi 5% b/v, kelompok IV pemberian rebusan daun pandan wangi dengan konsentrasi 10% b/v, dan kelompok V pemberian rebusan daun pandan wangi dengan konsentrasi 20% b/v.Berdasarkan hasil penelitian dan analisis data secara statistik, maka dapat disimpulkan bahwa rebusan daun pandan wangi yang digunakan dengan konsentrasi 5% b/v, 10% b/v, dan 20% b/v dapat menurunkan kadar glukosa darah pada mencit tetapi penurunannya tidak signifikan karena hasil penurunan rebusan daun pandan wangi yang digunakan dengan konsentrasi tersebut tidak jauh berbeda dengan penurunan Na-CMC sebagai kontrol negatif. Kata kunci : Daun pandan wangi (Pandanus amaryllifolius Roxb.), rebusan, glukosa darah, dan mencit (Mus musculus).
ABSTRAK Telah dilakukan penelitian mengenai Evaluasi Tingkat Kepuasan Pasien Terhadap Pelayanan Kefarmasian di Depo IGD Rumah Sakit TK II Pelamonia Makassar pada bulan juni tahun 2018. Tujuan penelitian ini adalah untuk mengetahui tingkat kepuasan pasien terhadap pelayanan kefarmasian di depo igd rumah sakit tk II pelamonia Makassar. Penelitian ini merupakan penelitian non eksperimental menggunakan metode cross-sectional dengan rancangan penelitian secara deskriptif dengan menggunakan analisis kuantiitatif. Jumlah sampel yang diambil pada penelitian ini sebanyak 100 responden. Pengambilan data diperoleh dengan penyebarann kuesioner dimana pertanyaan dalam kuesioner tersebut mencakup 5 dimensi yaitu keandalan, ketanggapan, kepastian, empati dan berwujud.Hasil penelitian menunjukkan bahwa berdasarkan hasil pengolahan data yang dilakukan maka diperoleh persentase responden merasa puas terhadap pelayanan kefarmasian yang dilakukan di Depo IGD Rumah Sakit TK II Pelamonia Makassar adalah 98 % dan selebihnya respoonden menyatakan tidak puas. Responden yang merasa puas terhadap keandalan sebanyak 96 % dan tidak puas sebanyak 4 %, untuk hasil dari ketanggapan, kepastian, empati dan berwujud adalah sebanyak 99 % responden menyatakan puas dan selebihnya kurang puas. Secara umum dapat disimpulkan bahwa kualitas pelayanan kefarmasian yang ada di Depo IGD Rumah Sakit TK II Pelamonia Makassar sudah cukup baik. Kata Kunci : Tingkat Kepuasan, Pelayanan Kefarmasian, dan Depo IGD Rumah Sakit TK II Pelamonia Makassar
Objective: This study aimed to determine the genotype distribution of the TNFSF4 (Tumor Necrosis Factor Superfamily 4) gene rs2205960 in Systemic Lupus Erythematosus (SLE) patients in Bandung, West Java, Indonesia.
Methods: This was a cross-sectional study; 84 genomic DNA samples were amplified, electrophoresed, then analyzed by DNA sequencing.
Results: The genotype distribution of the TNFSF4 gene rs2205960 in SLE patients showed that from 84 DNA samples, 55 patients are GG (65.48%), 25 patients are GT (29.76%), and 4 patients are TT (4.76%).
Conclusion: Results indicate that SLE patients in Bandung have a genotype distribution of the TNFSF4 rs2205960 gene that fulfills the Hardy-Weinberg equilibrium.
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