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This study shows that severe preeclamptic women with a platelet count <100,000/mm3 are hypocoagulable when compared to healthy pregnant women and other preeclamptic women.

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Correlated electron and light microscopic studies of the distribution, position, appearance, migration and fate of lymphocytes with relation to the intestinal epithelium of the young adult rat, mouse, hamster and man have been made. Under the conditions of this investigation, the lymphocytes which are normally present in the intestinal epithelium are intercellular in position, irrespective of their level within the epithelium. The great majority of these cells are located in the basal region of the epithelium, below the level of the epithelial cell nuclei. There was no evidence of lymphocytic degeneration. Lymphocytes migrated from the lamina propria into the epithelium and back again into the lamina propria, with no evidence of movement toward the free surface of the intestinal epithelium and extrusion into the lumen.The distribution, position, morphology, migration and fate of lymphocytes with relation to the intestinal epithelium of various laboratory animals and man have been the objects of numerous investigations which, unfortunately, have resulted in many conflicting interpretations. In a series of studies concerning these phenomena in the duodenal epithelium of the mouse and man, Andrew et al. ('45, '46, '47, '65) claimed that the lymphocytes are intracellular in position as evidenced by the "vacuoles" which surround them within the cytoplasm of the epithelial cells. They further observed that these intracellular lymphocytes undergo a series of degenerative changes characterized by pycnosis, fragmentation and sometimes vacuolation. They have also stated that these lymphocytes migrate toward the free surface of the intestinal epithelium and are extruded into the lumen, which supports their claim that the lymphocytes are being eliminated from the body in this fashion.Correlated electron and light microscopic studies of the intestinal epithelium of the rat, mouse, hamster and man have led us to question the above proposed concepts of the relation and appearance of lymphocytes to the intestinal epithelial cells and, therefore, have indicated to us the necessity for re-evaluation of these proposals. In the present communication, evidence will AM. J. ANAT., 121: 763-774.be presented to show that lymphocytes normally present in the intestinal epithelium are definitely intercellular in position, irrespective of their level within the epithelium. They exhibit no degenerative changes in this epithelial relationship, and their migration occurs from the lamina propria into the epithelium and back again into the lamina propria, with no evidence of any movement toward the free surface of the intestinal epithelium and extrusion into the lumen. MATERIALS AND METHODSThe observations which follow are based in part upon examination of portions of duodenum and ileum from 30 normal young adult female laboratory animals consisting of ten mice of a Swiss Albino stock, each weighing 80-90 gm; ten rats of the Sprague-Dawley strain, each weighing 120-130 gm; ten Syrian hamsters, each weighing 115-120 gm. In addition, huma...

Given the growing concern for the safety, cost and adequacy of blood supply, there is an increasing need for appropriate blood product utilization. Despite a number of consensus guidelines for the transfusion of allogeneic blood products, inappropriate blood transfusion continues. We discuss the quality assurance process for improvement in transfusion therapy including audit of blood transfusion. Audits identify areas of problems in transfusion practice which can be corrected by education of doctors, formulation of practice guidelines and algorithms. To improve the effectiveness of the audit programmes, the frequency of audits has to be maintained and there should be continual reinforcement of policies.