Objective. To determine if neurologic impairment is related to progressive autoimmune disease in 3 murine models of systemic lupus erythematosus (SLE): MRLl lpr, NZB, and NZBIWF,.Methods. Sensorimotor function, learning, and memory were tested within strains at specific ages, before and after the appearance of SLE. These parameters were also compared between strains for young and older lupus mice and their congenic controls with reduced autoimmune disease (MRL/lpr versus MRL/+ ; NZB versus NZB/xid).Results. Abnormal neurologic features were present at a much higher frequency in MRL/lpr mice than in age-matched MRL/+ control mice, and sensorimotor function deficits were also seen in NZB/WF, mice. Strains that develop lupus showed deficits on a waterescape, distal cue discrimination task and on a foodrewarded, proximal cue discrimination task, but the cognitive impairments were not global.Conclusion. MRL/lpr, NZB, and NZB/WF, mice differed in terms of which behaviors were impaired as well as when those impairments appeared.Abnormalities of neurologic and cognitive function are second only to renal disease in producing

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Sodium pentobarbital administered intravenously after acquisition in a one-trial passive avoidance task results in state dependent (drug dissociated) learning in male albino rats. Findings have methodological implications for drug-based research and theoretical implications for drug discrimination studies. Predictions based on a stimulus generalization hypothesis are not supported, whereas those based on an information storage hypothesis are supported.