Objective To determine the effectiveness of pelvis diameters in determining postoperative outcomes in men who underwent open radical cystectomy + urinary diversion, it is aimed to predict the factors that may affect the operative difficulty and possible surgical outcomes before the operation. Methods A total of 79 radical cystectomy patients operated in our institution with preoperative computed tomography (CT) were included the study. Pelvic dimensions; symphysis angle (SA), upper conjugate, lower conjugate, pelvic depth, apical depth (AD), interspinous distance (ISD), bone femoral width and soft tissue width were measured by preoperative CT. ISD index were defined as ISD/AD. Postoperative outcomes and indicators of operative difficulty were recorded. Regression analyses were used to predict perioperative and postoperative outcomes. Results Total of 96 complications were observed in 52 of the 79 patients in ninety days (65,8%) with a mean age of 68.25 years. There were significant correlations between SA and body mass index (BMI) with operative time (p = 0.006, p < 0.001; respectively). For estimated blood loss, there were significant correlations between preoperative hematocrit (p = 0,031). Analysis of multivariate logistic regression revealed that higher Charlson comorbidity index (CCI) and BMI were found to be significant predictors for major complications while CCI, pathological T stage and ISD index are prominent predictors for surgical margin positivity. Conclusions Pelvic dimensions are not significant with minor or major complications. However, operative time may be associated with SA. Also, narrow and deep pelvis may increase the risk of positive surgical margins.
Hematuria is defined as the presence of red blood cells in the urine and it may be observed microscopic or gross. Hematuria may originate from any site throughout the urinary tract, the glomerulus and interstitium or renal vasculature. Here, we present a 17-year-old boy who developed terminal hematuria after two months of treatment with isotretinoin for acne vulgaris. Radiological and cystoscopic assessment of the urinary system were normal. Isotretinoin treatment was stopped after dermatology consultation. In two weeks, terminal hematuria disappeared along with the dysuria, and the urine sample showed normal findings. Keywords: Acne vulgaris, adverse effect, gross hematuria, isotretinoin.
Background: Prostate cancer (PCa) is the second most common cancer in men worldwide and few studies have been reported investigating the effects of homeopathic therapy on PCa. Tarantula cubensis alcoholic extract (TCAE), is used in veterinary medicine as homeopathic medicine and there are various studies about the therapeutic efficacy of TCAE in treating different diseases. However, studies about the efficacy of TCAE in cancer treatment are limited. Aim: It was aimed to investigate the therapeutic efficacy of Tarantula cubensis alcoholic extract (TCAE), which is used as homeopathic medicine in prostate cancer (PCa). Methods: DU-145 and LNCaP cells were used as PCa cell lines, and HUVEC cells were used as control cell lines. The effect of TCAE (25, 50, 100, and 250 µM) on cell viability was evaluated by WST-1 analysis, and its apoptotic effects were assessed by Annexin V analysis and acridine orange staining. Results: TCAE decreased the viability rates in DU-145 and LNCaP cells in a time-dependent manner (p<0.01). The lowest viability rates for DU-145 and LNCaP cells were determined as 62.76%±4.21% and 55.68±1.84% at 250 and 25 μM doses, respectively, for 48 h. Moreover, TCAE did not induce any cytotoxic effect on HUVEC cells. Apoptotic cell rates were found as 30.45±0.78% and 45.02±1.32% in DU-145 and LNCaP cells at 250 and 25 μM TCAE, respectively. Furthermore, impaired cell/cytoplasm ratio, chromatin condensation, membrane blebbing, and vacuolar damage were observed in DU-145 and LNCaP cells. Conclusion: TCAE exerts cytotoxic and apoptotic effects on PCa cells. Additionally, due to androgen receptor status, LNCaP cells were more sensitive than DU-145 cells. However, further molecular studies are needed to determine the potential of TCAE as a new chemotherapeutic agent in PCa.
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