Summary. Adult female hair-loss (hl) mice (Mus musculus) were given incised wounds through the full thickness of the dorsal skin. At specified intervals thereafter (i. e., 1, 2, 4, 6, 12, and 20 hours), the animals were sacrificed and the wound sites were excised, processed, and sectioned: Enzyme and carbohydrate histochemical procedures were carried out on frozen and paraffin sections respectively. Nonspecific esterase was demonstrated in one hour wounds and a slight increase was observed through six hours. No other enzyme histochernical procedure gave a satisfactory reaction in the wound site. The Periodic Acid-Schiff reaction for carbohydrates revealed a steadily increasing reaction from one to six hours and a decrease in intensity by twelve hours. The causative agent for the PAS reaction may be serum glycoproteins transported to the wound site as part of the inflammatory process.
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