These beneficial effects make rhNRG-1 promising as a broad-spectrum therapeutic for the treatment of heart failure due to a variety of common cardiac diseases.

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Background The evidence of sarcopenia based on CT-scan as an important prognostic factor for critically ill patients has not seen consistent results. To determine the impact of sarcopenia on mortality in critically ill patients, we performed a systematic review and meta-analysis to quantify the association between sarcopenia and mortality. Methods We searched studies from the literature of PubMed, EMBASE, and Cochrane Library from database inception to June 15, 2020. All observational studies exploring the relationship between sarcopenia based on CT-scan and mortality in critically ill patients were included. The search and data analysis were independently conducted by two investigators. A meta-analysis was performed using STATA Version 14.0 software using a fixed-effects model. Results Fourteen studies with a total of 3,249 participants were included in our meta-analysis. The pooled prevalence of sarcopenia among critically ill patients was 41 % (95 % CI:33-49 %). Critically ill patients with sarcopenia in the intensive care unit have an increased risk of mortality compared to critically ill patients without sarcopenia (OR = 2.28, 95 %CI: 1.83–2.83; P < 0.001; I2 = 22.1 %). In addition, a subgroup analysis found that sarcopenia was associated with high risk of mortality when defining sarcopenia by total psoas muscle area (TPA, OR = 3.12,95 %CI:1.71–5.70), skeletal muscle index (SMI, OR = 2.16,95 %CI:1.60–2.90), skeletal muscle area (SMA, OR = 2.29, 95 %CI:1.37–3.83), and masseter muscle(OR = 2.08, 95 %CI:1.15–3.77). Furthermore, critically ill patients with sarcopenia have an increased risk of mortality regardless of mortality types such as in-hospital mortality (OR = 1.99, 95 %CI:1.45–2.73), 30-day mortality(OR = 2.08, 95 %CI:1.36–3.19), and 1-year mortality (OR = 3.23, 95 %CI:2.08 -5.00). Conclusions Sarcopenia increases the risk of mortality in critical illness. Identifying the risk factors of sarcopenia should be routine in clinical assessments and offering corresponding interventions may help medical staff achieve good patient outcomes in ICU departments.

A high-order time-domain approach for wave propagation in bounded and unbounded domains is proposed. It is based on the scaled boundary FEM, which excels in modelling unbounded domains and singularities. The dynamic stiffness matrices of bounded and unbounded domains are expressed as continued-fraction expansions, which leads to accurate results with only about three terms per wavelength. An improved continued-fraction approach for bounded domains is proposed, which yields numerically more robust time-domain formulations. The coefficient matrices of the corresponding continued-fraction expansion are determined recursively. The resulting solution is suitable for systems with many DOFs as it converges over the whole frequency range, even for high orders of expansion. A scheme for coupling the proposed improved high-order time-domain formulation for bounded domains with a high-order transmitting boundary suggested previously is also proposed. In the time-domain, the coupled model corresponds to equations of motion with symmetric, banded and frequency-independent coefficient matrices, which can be solved efficiently using standard time-integration schemes. Numerical examples for modal and time-domain analysis are presented to demonstrate the increased robustness, efficiency and accuracy of the proposed method.

The purpose of this paper was to analyze the prognosis of women with fulminant viral hepatitis in late pregnancy (FVHILP) by the Model for End-Stage Liver Disease (MELD) scoring system. A retrospective study involving patients admitted to two tertiary hospitals between January 1, 1994 and June 30, 2011 was undertaken. The relations between MELD scores and change of MELD score over time (ΔMELD) and prognosis during hospitalization were analyzed. Among the 54 patients with FVHILP, the MELD scores on admission were significantly higher in the non-survival group than those in the survival group (p < 0.05). Among the 26 FVHILP patients who underwent cesarean section, the MELD scores before and after cesarean section were both significantly higher in the non-survival group (p < 0.05). The ΔMELD scores (before operation and three days after operation) significantly increased in the non-survival group (p < 0.05). The concordance (c-statistic) values were all greater than 0.8. The MELD scoring system shows excellent short-term predictive value for the prognosis of FVHILP.

2015) 'A fully automatic polygon scaled boundary nite element method for modelling crack propagation.', Engineering fracture mechanics., 133 . pp. 163-178. Further information on publisher's website:http://dx.doi.org/10.1016/j.engfracmech.2014.11.011Publisher's copyright statement: NOTICE: this is the author's version of a work that was accepted for publication in Engineering Fracture Mechanics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reected in this document. Changes may have been made to this work since it was submitted for publication. A denitive version was subsequently published in Engineering Fracture Mechanics, 133, January 2015, 10.1016/j.engfracmech.2014.11.011. Additional information:Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details.

This paper assesses the impacts of the Three Gorges Dam, the South-North Water Transfer Project and other water abstractions on the probability of long-duration salt intrusions into the Yangtze River estuary. Studies of intrusions of saltwater into estuaries are typically constrained by both the short duration of discharge records and the paucity of observations of discharge and salinity. Thus, studies of intrusions of saltwater into estuaries typically seek to identify the conditions under which these intrusions occur, using detailed observations for periods of 20-60 days. The paper therefore first demonstrates a method by which to identify the conditions under which intense intrusions of longduration occur and then applies that method to analyse the effect of the three projects. The paper constructs a model of the relationship between salinity and discharge and then employs Monte Carlo simulation methods to reconstruct the probability of observing intrusions of differing intensities and durations in relation to discharge. The model predicts that the duration of intrusions with chlorinity ≥ 250 mg L −1 (or ≥ 400 or 500 mg L −1 ) increases as the number of consecutive days with discharge ≤ 12 000 m 3 s −1 (or ≤ 8000 m 3 s −1 ) increases. The model predicts that in 1950-2014, the number of consecutive days with chlorinity ≥ 250 mg L −1 averaged 21.34 yr −1 ; if the three projects operate according to their normal rules, that average would rise to 41.20 yr −1 . For a randomly selected year of discharge history from the period 1950-2014, under normal operating rules for these projects the probability of an intrusion rises from 0.25 (for 30-day intrusions) or 0.05 (for 60-day intrusions) to 0.57 or 0.28, respectively.

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