Lignocellulosic biomass is both low cost and abundant, and unlike energy crops, can escape associated ethical dilemmas such as arable land use and food security issues. However, their usage as raw material in a biorefinery implies an inherent upstream pretreatment step to access compounds of interest derived from lignocellulosic biomass. Importantly, the efficiency of this step is determinant for the downstream processes, and while many pretreatment methods have been explored, extrusion is both a very flexible and promising technology. Extrusion is well-known in both the polymer and pharmaceutical industries and has been used since the 18th century. However, as a pretreatment method for lignocellulosic biomass, extrusion is relatively new. The first use for this purpose dates back to the 1990s. Extrusion enjoys a high degree of flexibility due to the many available parameters, but an understanding of extrusion requires a knowledge of these parameters and the different relationships between them. In this paper, we present a concise overview of lignocellulosic biomass extrusion by reviewing key extrusion parameters and their associated extruder design components and operating conditions.