Introduction: The misuse of drugs among students has become a serious problem. In economically deprived countries most episodes of illness are treated by self medication. Major problems related to self medication are: wastage of resources, increased resistance of Pathogens, and generally entails serious health hazards such as adverse reaction and prolonged suffering. Objective: To assess the prevalence and associated factors of self medication practice among non health professional students of university of Gondar, Northwest Ethiopia. Methods: Institutional based cross sectional study was carried out on 607 non health professional students of university of Gondar; Stratified systematic random sampling technique was employed. A structured and pretested self-administered questionnaire was used to collect data, the collected data were entered using Epi-info version 3.5.3 and SPSS version 20 were used for data entry and analysis respectively. Results: A total of 607 students were participated giving a response rate of 98.02%. From the respondents 226(38%) practiced self medication. The common perceived illnesses reported were headache/Fever 127(56.19%), abdominal pain 59(26.10%) and respiratory tract infections 35(15.48%). Males were two times more likely to practice self medication (AOR: 2.00, 95% CI: 1.41-2.86) than females. Conclusion: The prevalence of self medication among non health professional students is high. In the bivariate and multivariate logistic analysis males were two times more likely practiced self medication than females, and being students from college of Business and economics are 61.5% less likely to practiced self medication than Technology students.
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